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Aqueous ophthalmic composition

a technology of ophthalmic composition and water, which is applied in the field of aqueous ophthalmic composition, can solve the problems of large difficulty in handling, and production efficiency, and achieve the effects of shortening the defoaming time, reducing the variation in the amount of drip, and improving production efficiency

Inactive Publication Date: 2014-01-02
ROHTO PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention relates to a method for reducing the time needed to defoam an aqueous ophthalmic composition containing polyoxyethylene castor oil, which involves adding polyoxyethylene castor oil with a specific number of moles of added ethylene oxide. This results in a faster dissolution time and allows for quicker detection of foreign particles during production. Additionally, the amount of drip and turbidity in the final product is reduced. This method improves the quality and appearance of the aqueous ophthalmic composition. Overall, the invention enhances production efficiency and quality.

Problems solved by technology

Further, an aqueous ophthalmic composition such as eye drops in which foam is generated shows large variation in the drip amount per use.
In particular, for eye drops or solutions for wearing a contact lens used in a relatively small amount each time, users have difficulty controlling the amount used per use, thus causing disadvantages such as difficulty in handling.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation examples

[0128]According to the formulations shown in Tables 13 and 14, eye drops (Preparation Examples 1 to 8), eye washes (Preparation Examples 9 and 10), and eye drops for soft contact lenses (Preparation Example 11) are prepared. Retinol palmitate is vitamin A palmitate manufactured by Wako Pure Chemical Industries, Ltd. (900,000 to 1,050,000 IU / g).

TABLE 13Unit: w / v %PreparationPreparationPreparationPreparationPreparationPreparationExample 1Example 2Example 3Example 4Example 5Example 6Eye dropsEye dropsEye dropsEye dropsEye dropsEye dropsPolyoxyethylene——0.01—0.5—castor oil 3Polyoxyethylene0.10.50.10.5—0.25castor oil 10Castor oil—0.10.5—0.05—Retinol0.01—0.0050.020.0050.03palmitate(10,000(50,00(20,000(50,00(30,000IU)IU)IU)IU)IU)Epsilon-———3——aminocaproicacidBerberine0.050.05—0.010.01—sulfate hydrateChlorpheniramine0.03———0.030.015maleatePyridoxine—0.1————hydrochlorideTocopherol—————0.01acetatePotassium11—0.050.5—L-aspartateAminoethylsulfonic10.05—0.10.51acidSodium—0.20.1———chondroitinsulf...

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Abstract

This invention relates to an aqueous ophthalmic composition comprising (A) polyoxyethylene castor oil in which the number of moles of added ethylene oxide is 2 to 30, and (B) at least one member selected from the group consisting of castor oil and vitamin A. According to the aqueous ophthalmic composition of the present invention, the defoaming time can be reduced even when foam is generated by vibration or impact.

Description

BACKGROUND OF INVENTION[0001]1. Technical Field[0002]The present invention relates to an aqueous ophthalmic composition. More specifically, the present invention relates to an aqueous ophthalmic composition having a reduced defoaming time.[0003]2. Background Art[0004]In the field of ophthalmology, solubilizing agents are added to a variety of preparations. In particular, in aqueous ophthalmic compositions, various solubilizing agents are added for the purpose of helping dissolution of biologically active components and additives with relatively low water solubility, and the like. A surfactant can be given as an example of the solubilizing agents used in the field of ophthalmology. It is known that polyoxyethylene castor oil is a nonionic surfactant and is added to an aqueous ophthalmic composition to help dissolve other components (JP2005-298448A).[0005]An aqueous composition containing a surfactant is known to easily foam, and foam is generated when vibration or impact is applied d...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/07A61K47/14
CPCA61K31/07A61K47/14A61K9/0048A61K31/69A61P27/02A61P3/02A61P43/00A61K2300/00A61L12/14
Inventor NAKATA, ATSUKO
Owner ROHTO PHARM CO LTD