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Compositions, methods and kits relating to resistin

a technology of resistin and composition, applied in the field of compositions, methods and kits relating to resistin, can solve the problems of ineffective compounding of serum glucose levels in absence of insulin, modest weight gain in rodents and humans, chronic tzd therapy, etc., and achieve the effects of increasing blood glucose levels in mammal, and increasing blood glucose level in mammal

Inactive Publication Date: 2014-01-30
THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes a method for increasing insulin-stimulated glucose uptake in cells by reducing the levels of resistin, a protein that inhibits insulin signaling. This can be achieved by administering an anti-resistin compound to cells or by administering resistin to mammals. The technical effect of this is an improvement in blood glucose levels in mammals.

Problems solved by technology

These compounds are ineffective at lowering serum glucose levels in the absence of insulin.
Chronic TZD therapy also leads to modest weight gain in rodents and humans.
However, none of these compounds binds to PPAR-γ with affinities in the nanomolar range.

Method used

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  • Compositions, methods and kits relating to resistin
  • Compositions, methods and kits relating to resistin
  • Compositions, methods and kits relating to resistin

Examples

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example

Resistin, a Novel Insulin Sensitivity Modulator

[0416]The experiments presented in this example may be summarized as follows.

[0417]A novel TZD-suppressible gene, resistin (previously referred to as TSG-1 for TZD-suppressible gene 1), has been identified. The data disclosed herein demonstrate that expression of Resistin is markedly and specifically suppressed in a cell contacted by the powerful antidiabetic compounds TZDs.

[0418]The data disclosed herein suggest that resistin is the mechanistic link between obesity, insulin resistance, and type 2 diabetes (NIDDM), and is a downstream target of TZDs. More specifically, the data disclosed herein demonstrate that resistin is expressed only in fat cells. Further, the data demonstrate that resistin is secreted by fat cells, and that the protein can be detected circulating in the bloodstream.

[0419]The data disclosed herein further demonstrate that serum resistin levels are increased by high fat diets associated with diabetes and obesity, and...

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Abstract

The invention relates to novel nucleic acids encoding a mammalian resistin gene, and proteins encoded thereby, whose expression is suppressed by the antidiabetic compounds thiazolidinediones. The invention further relates to methods of treating and detecting type 2 diabetes and Syndrome X comprising modulating or detecting resistin expression and / or production and activity of resistin polypeptide.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of U.S. patent application Ser. No. 11 / 590,736, filed Oct. 31, 2006, which is a continuation of U.S. patent application Ser. No. 09 / 986,234, filed Oct. 22, 2001, now abandoned, which is a continuation of International Patent Application No PCT / US00 / 11272, filed Apr. 27, 2000, now expired, which claims the benefit of the priority of U.S. Provisional Patent Application No. 60 / 131,263, filed Apr. 27, 1999, now expired. Each of these applications is incorporated by reference herein in its entirety.BACKGROUND OF THE INVENTION[0002]Non-insulin-dependent diabetes mellitus (NIDDM) is a common, chronic disease that is a major cause of morbidity and mortality in industrialized societies. NIDDM affects 95% of diabetics and afflicts more than 5% of the world's population. NIDDM has a strong genetic component and is tightly linked to obesity. The disorder is characterized by severe tissue resistance to the effects of...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C07K14/575C07K16/26A61K38/00C07K14/47
CPCC07K16/26C07K14/575A01K2217/05A61K38/00C07K14/47
Inventor LAZAR, MITCHELL A.
Owner THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
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