pH AND BUFFER MANAGEMENT SYSTEM FOR HEMODIALYSIS SYSTEMS

a technology of hemodialysis and buffer management system, which is applied in the direction of membrane technology, multi-stage water/sewage treatment, other medical devices, etc., can solve the problems of difficult to predict the changes in dialysate ph and bicarbonate concentration that will occur

Inactive Publication Date: 2014-06-12
MOZARC MEDICAL US LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0004]In any embodiment, a urea sensor can be provided to allow for the determination of the urea content of a dialysate flowing to a dialysate regeneration unit. A controller can be provided having a processor to determine the bicarbonate buffer composition of a dialysate resulting from removal of urea content from the dialysate by contacting or processing with the dialysate regeneration unit and can also optionally include a sodium management system for adjusting the sodium ion concentration of the dialysate. Moreover, in any embodiment, the determination of the bicarbonate buffer composition can allow for a controlled amount of bicarbonate buffer to be added to the dialysate to form a dialysate with

Problems solved by technology

Because of this, it becomes difficult to predict the changes in dialysate pH

Method used

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[0028]Unless defined otherwise, all technical and scientific terms used herein generally have the same meaning as commonly understood by one of ordinary skill in the relevant art. The definitions provided herein should not be rigidly construed without taking into account the context and other ascribed meanings provided, or by their use, in other parts of the specification, claims, and drawings.

[0029]The articles “a” and “an” are used herein to refer to one or to more than one (i.e., to at least one) of the grammatical object of the article. By way of example, “an element” means one element or more than one element.

[0030]The term “acid or base equivalents” refers to an equivalent acid or base donating or accepting an equal number of moles of hydrogen or hydronium ions per mole of the acid to which the equivalent acid is being equated, or mole of hydroxide ions to which the equivalent base is being equated.

[0031]The term “cation infusate pump” historically known as an “acid...

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Abstract

Systems and methods for managing the pH of a dialysate fluid during hemodialysis therapy. The systems and methods adjust dialysate pH and buffer concentration to generate a predetermined total bicarbonate buffer concentration in a dialysate entering a dialyzer.

Description

FIELD OF THE INVENTION[0001]The invention relates to systems and methods for managing the pH of a dialysate fluid during hemodialysis therapy. The invention adjusts dialysate pH and buffer concentration to generate a predetermined total bicarbonate buffer concentration in a dialysate entering a dialyzer.BACKGROUND[0002]During hemodialysis, the dialysate pH and buffer concentration play a critical role in patient outcomes. The dialysate pH and buffer concentration are specified for a patient based on the acid-base status of the patient. Acidotic patients can be treated by increasing their bicarbonate buffer levels and patients with alkalosis can be treated by decreasing their bicarbonate levels. A method to manage pH and buffer dialysate concentration is especially important with systems that contain a component that may change the pH level and bicarbonate concentration to unknown values. For example, regenerative hemodialysis systems, such as the Recirculating Dialysate System (“RED...

Claims

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Application Information

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IPC IPC(8): A61M1/16
CPCA61M1/1696A61M1/287A61M1/34A61M1/3413A61M1/1605A61M1/165A61M1/3437A61M2205/33A61M2205/3324A61M1/16A61M2205/50A61M1/3406
Inventor PUDIL, BRYANT J.GERBER, MARTIN T.LURA, DAVID B.MEYER, THOMAS E.
Owner MOZARC MEDICAL US LLC
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