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Toxoid preparation and uses thereof

a technology of toxoid preparations and preparations, applied in the field of toxoid preparations, can solve the problems of reducing the potency of vaccines, difficult control of procedures,

Inactive Publication Date: 2017-01-05
ARYTHA BIOSCIENCES LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a toxoid preparation and an immunogenic composition that can prevent damage caused by a toxin. The toxoid preparation is made by attaching a non-disrupted and non-denatured toxin to a particulate vector that minimizes damage. The immunogenic composition is made by using the toxoid preparation to elicit an immune response in a subject, preventing the toxin from causing harm. The invention can be used to manufacture a vaccine for protecting against the toxin.

Problems solved by technology

However, these procedures can be difficult to control, since inadequate denaturation can leave residual toxicity6.
Extended denaturation, on the other hand, can greatly compromise the toxoid's antigenic presentation, thereby reducing the vaccine's potency7, 8.

Method used

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  • Toxoid preparation and uses thereof
  • Toxoid preparation and uses thereof
  • Toxoid preparation and uses thereof

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Embodiment Construction

[0021]The practice of the present invention will employ, unless otherwise indicated, conventional techniques of nanotechnology, nano-engineering, molecular biology (including recombinant techniques), microbiology, cell biology, biochemistry, immunology, and pharmacology, which are within the skill of the art. Such techniques are explained fully in the literature, such as, Molecular Cloning: A Laboratory Manual, 2nd ed. (Sambrook et al., 1989); Oligonucleotide Synthesis (M. J. Gait, ed., 1984); Animal Cell Culture (R. I. Freshney, ed., 1987); Methods in Enzymology (Academic Press, Inc.); Current Protocols in Molecular Biology (F. M. Ausubel et al., eds., 1987, and periodic updates); PCR: The Polymerase Chain Reaction (Mullis et al., eds., 1994); and Remington, The Science and Practice of Pharmacy, 20th ed., (Lippincott, Williams & Wilkins 2003).

[0022]Unless defined otherwise, all technical and scientific terms used herein have the same meaning as is commonly understood by one of ordi...

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Abstract

The present invention relates to toxoid preparations comprising a non-disrupted and / or a non-denatured toxin associated with a particulate vector that minimizes or precludes said toxin from inflicting damage at an action site of said toxin. The present invention also relates to immunogenic compositions or vaccines comprising the toxoid preparations, and the methods of using the toxoid preparations, immunogenic compositions or vaccines.

Description

I. CROSS REFERENCE TO RELATED APPLICATIONS[0001]The present application claims priority benefit to U.S. Provisional Patent Application No. 61 / 910,861, filed on Dec. 2, 2013, the content of which is incorporated by reference herein in its entirety for all purposes.II. FIELD OF THE INVENTION[0002]The present invention relates to toxoid preparations comprising a non-disrupted and / or a non-denatured toxin associated with a particulate vector that minimizes or precludes said toxin from inflicting damage at an action site of said toxin. The present invention also relates to immunogenic compositions or vaccines comprising the toxoid preparations, and the methods of using the toxoid preparations, immunogenic compositions or vaccines.III. BACKGROUND OF THE INVENTION[0003]Toxins, e.g., bacterial toxins, are soluble factors that alter the normal metabolism of host cells and inflicts adverse effects. These virulent factors are employed by bacteria for pathogenesis and give rise to symptoms in d...

Claims

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Application Information

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IPC IPC(8): A61K39/02A61K9/16A61K39/112A61K39/085
CPCA61K39/107A61K39/085A61K2039/6018A61K39/0283A61K9/16Y02A50/30
Inventor HU, CHE-MING JACK
Owner ARYTHA BIOSCIENCES LLC
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