Compositions and methods for disinfecting and cleaning contact lenses
a technology for disinfecting and cleaning contact lenses, applied in disinfection, chemicals, botany apparatus and processes, etc., can solve the problems of lens surface hydrophobic properties, high contact angle, and possible disruption of tear film
Inactive Publication Date: 2017-05-25
ALCON INC
View PDF4 Cites 0 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Benefits of technology
The solution enhances the wettability of contact lenses while preventing excessive foaming during hydrogen peroxide neutralization, ensuring effective disinfection and comfort by maintaining a stable tear film.
Problems solved by technology
If the contact lens material exhibits mostly hydrophobic properties on the lens surface, the tear film may be disrupted.
The surface is hydrophobic if a drop of aqueous fluid does not spread, thereby resulting in a high contact angle.
Additionally, the presence of silicone groups in silicone hydrogel materials results in a lens surface having hydrophobic properties.
Although modifying the surface can improve biocompatibility, it has also been reported that some silicone hydrogel materials accumulate lipids over time, and that this build-up may result in a decrease in the wettability of the silicone hydrogel lens material and surface.
However, U.S. Patent application Publication No. 2011 / 0300019 (Ketelson et al.) discloses that such surfactants do not wet silicone hydrogel lenses efficiently.
However, the surfactants disclosed are all present in amounts above 0.1% and, because of excessive foaming, are incompatible with the platinum catalyst disc typically used to deactivate hydrogen peroxide in the lens disinfection systems.
The hydrogen peroxide is degraded by a catalase released into the solution and causes “a reduced amount of foam.” However, such compositions cause excessive foaming when a platinum catalyst is used to decompose the hydrogen peroxide.
However, it has been found that EO-BO copolymers may cause excessive foaming when used in peroxide-based disinfecting solutions during neutralization, for example, with platinum catalyst discs.
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment Construction
[0016]Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Generally, the nomenclature used herein and the laboratory procedures are well known and commonly employed in the art. Conventional methods are used for these procedures, such as those provided in the art and various general references. Where a term is provided in the singular, the inventors also contemplate the plural of that term. The nomenclature used herein and the laboratory procedures described below are those well known and commonly employed in the art. As employed throughout the disclosure, the following terms, unless otherwise indicated, shall be understood to have the following meanings.
[0017]The abbreviation “PEO-PPO” means poly (oxyethylene)-poly(oxypropylene).
[0018]The abbreviation “PEO-PBO” means poly(oxyethylene)-poly(oxybutylene).
[0019]The abbreviation “PEO-PBO-PEO” means poly(...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
| Property | Measurement | Unit |
|---|---|---|
| weight percent | aaaaa | aaaaa |
| weight percent | aaaaa | aaaaa |
| weight percent | aaaaa | aaaaa |
Login to View More
Abstract
This invention relates generally to disinfection and cleaning systems for medical devices. In a preferred embodiment, the invention relates to compositions, methods and articles for simultaneously cleaning and disinfecting contact lenses. The present invention is directed to ophthalmic compositions containing one or more block copolymers referred to as (polyoxyethylene)-(poly-oxybutylene) block copolymers (“PEO-PBO”). The invention is particularly directed to the use of PEO-PBO di-block copolymers as non-foaming wetting agents in peroxide-based compositions for disinfecting contact lenses.
Description
[0001]This application claims the benefit under 35 USC §119 (e) of U.S. provisional application No. 61 / 883,365 filed 27 Sep. 2013, incorporated by reference in its entirety.FIELD OF THE INVENTION[0002]This invention relates generally to disinfection and cleaning systems for medical devices. In a preferred embodiment, the invention relates to compositions, methods and articles for simultaneously cleaning and disinfecting contact lenses. The present invention is directed to ophthalmic compositions containing one or more block copolymers referred to as (polyoxyethylene)-(poly-oxybutylene) di-block copolymers (“PEO-PBO”). The invention is particularly directed to the use of PEO-PBO di-block copolymers as non-foaming wetting agents in peroxide-based compositions for disinfecting contact lenses.BACKGROUND OF THE INVENTION[0003]Disinfecting solutions for use with contact lenses are well known in the art and the use of such lenses involves a daily disinfecting treatment regimen. The two mos...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More Patent Type & AuthorityApplications(United States)
IPC IPC(8): A01N25/30A01N59/00A61L12/12
CPCA01N25/30A01N59/00A61L12/128A61P27/02A61L12/124
InventorMUYA, LEROY WAINAINAKETELSON, HOWARD ALLEN
OwnerALCON INC