Ph and moisture indicator devices and formulations
a technology of moisture indicator and ph indicator, which is applied in the direction of chemical indicator analysis, moisture content analysis, instruments, etc., can solve the problems of direct measurement of wound ph levels, unsuitable for ph monitoring during wound healing, and disruption or irritation of wounds, so as to reduce the subjectivity of bandage readings, reduce variance, and reduce the effect of variation
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examples section 1 and 2
[0256]A sample of the pad from an Opsite Post-Op dressing (Smith & Nephew, Inc) was prepared in different samples, and each sample was covalently bound with one or a combination of phenylazo dyes, selected from GJM-514, GJM-492, GJM-546, and GJM-534. The structures of these dyes are shown in Table 1. It was discovered that these dyes had colour-changing characteristics that varied according to changes in pH. The Post-Op samples were covalently bound with GJM-514 alone or with GJM-514 combined with one of GJM-492, GJM-546 and GJM-534 using the method as described above in relation to FIGS. 1-3. The Post-Op material was exposed to buffered solutions having a pH of 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9 and 9.5. Photographs were taken of each sample to demonstrate the visible changes in colour. A colour pen (for example, Dr Lange Colour Pen), a pen-type colorimeter was used to detect marginal colour changes which arc undetectable by the human eye. Colour pen measurements include, but arc no...
example 1
ad Dyed with GJM-514
[0266]A sample of the pad from an Opsite Post-Op dressing (Smith & Nephew) was covalently bound with the dye GJM-514 was exposed to buffered solutions at pH 5-pH 9.5. The panel of photographs in FIG. 3 demonstrates the colour change of GJM-514 over this pH range, going from yellow in colour (at pH5) to pink (at pH 9.5).
[0267]Table 2 illustrates the colour pen measurements (L*, a* and b*) of the colour of the GJM-514 dye over a pH range of pH 5-pH 9.5. An optimal dye for use as a pH indicator is one which demonstrates a linear change in a measurement of a specific parameter of colour (for example L*, a* orb*) over a broad pH range. Outside of the linear region, the dye is either unable to change colour in response to a change in pH or the change in colour is so minimal that it is undetectable.
TABLE 2pHL*a*b*563.3−1.941.55.569.20.336.2665.71.435.16.559.31.235.5756.9233.67.555.44.830.6846.810.421.48.543.315.615.4940.221.38.79.537.524.84.9
[0268]FIGS. 4A and 4B illust...
example 2
ad Dyed with GJM-514: GJM-492 (1:1)
[0272]A sample of the pad from an Opsite Post-Op dressing (Smith & Nephew) was covalently bound with the dye GJM-514: GJM-492 at a 1:1 ratio was exposed to buffered solutions at pH 5-pH 9.5. The panel of photographs in FIG. 5 demonstrates the colour change over this pH range, going from yellow in colour (at pH 5) to orange in colour (at pH 9.5).
[0273]Table 3 illustrates the colour pen measurements (L*, a* and b*) of the colour of the GJM-514: GJM-492 dye combination over a pH range of pH 5-pH 9.5.
TABLE 3pHL*a*b*553.811.543.35.550.717.437.9645.323.937.56.540.429.935.4739.730.933.87.539.930.429.9834.531.529.28.537.42829.3933.830.7259.533.131.323.2
[0274]FIG. 6A illustrates the L* measurements taken with the colour pen presented graphically. The L* results presented in FIG. 6A show that the value for L* decreases over the range of pH 5.5 to pH 9.5 but does not follow a linear downward trend. The L* value is therefore not considered to be a reliable ind...
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