Blood Plasma Fractions as a Treatment for Aging-Associated Cognitive Disorders

Abstract

Methods and compositions for treating and / or preventing aging-related conditions are described. The compositions used in the methods include fractions derived from blood plasma with efficacy in treating and / or preventing aging-related conditions such as neurocognitive disorders.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]Pursuant to 35 U.S.C. § 119 (e), this application claims priority to the filing date of U.S. Provisional Patent Application No. 62 / 412,258, filed Oct. 24, 2016; the disclosure of which application is herein incorporated by reference.FIELD OF THE INVENTION[0002]This invention pertains to the prevention and treatment of aging-associated disease. The invention relates to the use of blood products, such as blood plasma fractions, to treat and / or prevent conditions associated with aging, such as neurocognitive and neurodegenerative disorders.BACKGROUND[0003]The following is offered as background information only and is not admitted to be prior art to the present invention.[0004]Aging is an important risk factor for multiple human diseases including cognitive impairment, cancer, arthritis, vision loss, osteoporosis, diabetes, cardiovascular disease, and stroke. In addition to normal synapse loss during natural aging, synapse loss is an early pa...

AI Technical Summary

Benefits of technology

The present invention is based on the use of blood products to treat and prevent age-related disorders such as cognitive impairment, dementia, and neurodegenerative disease. The invention recognizes the need for new therapies for these disorders and proposes the use of blood plasma fractions with efficacy in treating and preventing these conditions. The invention also relates to proteins identified in blood plasma fractions that may have therapeutic potential or act as targets for inhibition by other agents. The patent text also describes methods of treatment using blood plasma fractions, such as those obtained from a blood fractionation process or young donor pools. The invention also includes the monitoring of cognitive improvement in individuals treated with blood plasma fractions.

Problems solved by technology

Aging affects all tissues and functions of the body including the central nervous system, and a decline in functions such as cognition, can severely impact quality of life.

Treatment for cognitive decline and neurodegenerative disorders has had limited success in preventing and reversing impairment.

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