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Modulation of Wnt5a to Treat Glaucoma

a glaucoma and wnt5a technology, applied in the field of wnt5a modulation to treat glaucoma, can solve the problems of limited efficacy of existing eye drops or oral medications, permanent blindness without treatment, and no cure for glaucoma

Pending Publication Date: 2020-05-21
RGT UNIV OF CALIFORNIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent text reveals that Wnt5a is a protein found on Schlemm's canal, which can regulate the expression of other genes. By inhibiting Wnt5a, researchers have been able to effectively lower intraocular pressure (IOP) in animals. The technical effect of this patent text is the discovery of a new mechanism for regulating IOP and potential for reducing glaucoma-related damage.

Problems solved by technology

A major risk factor for this disease is increased intraocular pressure (IOP), which can damage the optic nerve and cause permanent blindness without treatment.
Currently, there is no cure for glaucoma.
Existing eye drops or oral medications are of limited efficacy with many side effects, and surgeries often fail with scar formation and fibrosis.
When canal resistance increases with age or under pathological situation, IOP is elevated leading to glaucoma with irreversible optic nerve damage and vision loss.

Method used

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Examples

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prototypical examples

[0024]Wnt5a is expressed on human primary SC cells in culture and mouse SC in vivo. Wnt5a expression is regulated with sheer stress change, as analyzed by quantitative real-time PCR assay. We also demonstrate that Wnt5a expression in human SC cells can be down-regulated by Wnt5a-specific siRNA, which affects SC cell functions as well. In SC-specific Wnt5a gene conditional knockout mice IOP elevation induced in a glaucoma model is significantly reduced compared to control littermates. No significant difference was found in baseline IOP between the knockout mice and control littermates. Compared with the control littermates that had IOP elevation at all time-points studied, Wnt5a knockout mice only showed elevated IOP at the early (within 24 hours) but not later time points, indicating an unsustainable IOP increase with Wnt5a intervention. We also demonstrate that wnt5a intervention is effective in protecting retinal nerve fiber layer and increasing SC permeability, a target for enhan...

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Abstract

Glaucoma or pathogenic intraocular pressure is treated by locally administering to an eye in need thereof formulations of a Wnt5a inhibitor.

Description

[0001]This invention was made with government support under Grant Numbers EY017392 and EY028995 awarded by the National Institutes of Health. The government has certain rights in the invention.INTRODUCTION[0002]Glaucoma is a major health problem which affects over 3 million Americans and 60 million people worldwide. It is estimated that 111.8 million people will be affected by this disease worldwide in 2040. A major risk factor for this disease is increased intraocular pressure (IOP), which can damage the optic nerve and cause permanent blindness without treatment. Currently, there is no cure for glaucoma. Existing eye drops or oral medications are of limited efficacy with many side effects, and surgeries often fail with scar formation and fibrosis.[0003]Aqueous humor is the clear colorless liquid that fills the anterior and posterior chambers of the eye. It is produced by the ciliary body at the posterior chamber and exits the anterior chamber angle through the conventional pathway...

Claims

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Application Information

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IPC IPC(8): C07K14/47C12N15/11C07K16/22A61K31/335C07K7/06A61K9/06A61P27/06
CPCA61K9/0048C07K14/4703A61K9/06C12N15/111A61K31/335A61K2039/505A61K2039/54A61K38/00A61P27/06C07K16/22A61K9/0019C07K7/06A61K39/395A61K9/10A61K9/08C12N15/113C12N2310/14C07K2317/76A61K38/08A61K38/18A61K48/00A61K31/713A61P27/00
Inventor CHEN, LU
Owner RGT UNIV OF CALIFORNIA