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53 results about "APPETITE SUPPRESSANTS" patented technology

Use of Polymeric Materials with Other Substances for Improved Performance

Methods of enabling or improving the ability of a hydrogel to swell in the stomach of an animal and/or increasing the amount of time said hydrogel remains swollen in the stomach are described herein. In one embodiment, a polymer is administered in combination with one or more pH modifying agents which raise and maintain the pH of the micro environment of the polymer and/or the stomach in order inducing swelling in the polymer. The polymer can be a homopolymer, a copolymer, or a polymer blend or composite. In one embodiment, the polymer is a superabsorbent polymer (“SAP”). The polymers can also be administered with one or more active agents, such as appetite suppressants. The pH modifying agent and/or the active agent can be administered simultaneously with the polymer in the same dosage form, simultaneously with the polymer in separate dosage forms, or sequentially. The compositions are formulated for oral administration. The formulation can include drugs for delivery to the stomach, such as antibiotics, or the hydrogel can be used as a filler, for example, for obesity control. The formulation an also be used to enhance gastric retention, for example, for controlled drug delivery. Methods of delivering a drug are also described herein, along with medicaments for carrying out the methods of the present invention.
Owner:GELESIS

Novel compounds and their effects on feeding behaviour

The invention provides a peptide comprising the amino acid sequence given below, together with use of the peptide and methods associated therewith. The peptide finds particular use as an appetite suppressant and in the treatment of obesity. Xaa1 Xaa2 Xaa3 Gly4 Thr5 Phe6 Thr7 Ser8 Asp9 Tyr1O Ser1 1 Lys12 Tyr13 Leu14 Xaa15 Xaa16 Xaa17 Xaa18 Xaa19 Xaa20 Xaa21 Xaa22 Xaa23 Xaa24 Trp25 Leu26 Xaa27 Xaa28Xaa29 Xaa30 Xaa31 Xaa32 Lys33 Asn34 Asn35 Ue36 Ala37; wherein: Xaa1 is His1 or D-His1, Xaa2 is Ser2 or Ala2, Xaa3 is Gln3 or Asp3; Xaa15 Xaa16 Xaa17 Xaa18 Xaa19 Xaa20 Xaa21 Xaa22 Xaa23 Xaa24 is: G1u1 5 Glu16 G1u17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24, Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24, Glu15 Glu16 Glu17 Leul18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24, Glu15 Glu16 Glu17 Leul18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24, Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24, Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24, Glu15 Glu16 Glu17 Ilel18 Val19 Lys20Tyr21 Phe22 Ile23 Glu24, Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24, Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24, Glu15 Gln16 G1u17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu2 3 Gln24, Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24, Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ue23 Gln24, Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24, Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24, Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24, Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24, or Asp15 Ser16 Arg17 Arg18Ala19 Gln20 Asp21 Phe22 Val23 Gln24; Xaa27 Xaa28 Xaa29 Xaa30 Xaa31 Xaa32 is: Met27 Asn28 Thr29 Lys30 Arg31 Asn32, Lys27 Asn28 Ala29 Gly30 Pro31 Ser32, or Lys27 Asn28 Gly29 Gly30 Pro31 Ser32 or a pept ide as set out above in which residue Asn34 is replaced with Asp34; or a peptide as set out above in which Xaa3 is Glu3.
Owner:IMPERIAL INNOVATIONS LTD

Novel compounds and their effects on feeding behaviour

The invention provides a peptide comprising the amino acid sequence given below, together with uses of the peptide and methods associated therewith. The peptide finds particular use as an appetite suppressant and in the treatment of obesity.

Xaa1 Xaa2 Xaa3 Gly4 Thr5 Phe6 Thr7 Ser8 Asp9 Tyr10
Ser11 Lys12 Tyr13 Leu14 Xaa15 Xaa16 Xaa17 Xaa18
Xaa19 Xaa20 Xaa21 Xaa22 Xaa23 Xaa24 Trp25 Leu26
Xaa27 Xaa28 Xaa29 Xaa30 Xaa31 Xaa32 Lys33 Asn34
Asn35 Ile36 A1a37;
wherein:
Xaa2 is His1 or D-His1,
Xaa2 is Ser2 or Ala2,
Xaa3 is Gln3 or Asp3;
Xaa15 Xaa16 Xaa17 Xaa18 Xaa19 Xaa20 Xaa21 Xaa22
Xaa23 Xaa24 is:
Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22
Leu23 Glu24,
Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22
Leu23 Gln24,
Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22
Ile23 Glu24,
Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22
Ile23 Gln24,
Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22
Leu23 Glu24,
Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22
Leu23 Gln24,
Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22
Ile23 Glu24,
Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22
Ile23 Gln24,
Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22
Leu23 Glu24,
Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22
Leu23 Gln24,
Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22
Ile23 Glu24,
Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22
Ile23 Gln24,
Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22
Leu23 Glu24,
Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22
Leu23 Gln24,
Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22
Ile23 Glu24,
Glu15 Gln16 Glu17 lle18 Val19 Lys20 Tyr21 Phe22
Ile23 Gln24,
or
Asp15 Ser16 Arg17 Arg18 Ala19 Gln20 Asp21 Phe22
Val23 Gln24;
Xaa27 Xaa28 Xaa29 Xaa30 Xaa31 Xaa32 is:
Met27 Asn28 Thr29 Lys30 Arg31 Asn32,
Lys27 Asn28 Ala29 Gly30 Pro31 Ser32,
or
Lys27 Asn28 Gly29 Gly30 Pro31 Ser32
or a peptide as set out above in which residue Asn34 is replaced with Asp34;
or a peptide as set out above in which Xaa3 is Glu3;
with the proviso that if

Xaa15 Xaa16 Xaa17 Xaa18 Xaa19 Xaa20 Xaa21 Xaa22
Xaa23 Xaa24 is
Asp15 Ser16 Arg17 Arg18 Ala19 Gln20 Asp21 Phe22
Val23 Gln24,
then
Xaa27 Xaa28 Xaa29 Xaa30 Xaa31 Xaa32 is not
Met27 Asn28 Thr29 Lys30 Arg31 Asn32.
Owner:IMPERIAL INNOVATIONS LTD
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