8 results about "Endorphins" patented technology

A pomalidomide derivative exhibiting effects better than those of pomalidomide, a preparation method therefor, and use thereof. The pomalidomide derivative has excellent binding force to cereblon, has low cytotoxicity, has a low potential for causing teratogenic side effects, can regulate the expression of TNF-α and proinflammatory cytokines, and has excellent in vivo pharmacokinetic stability even while inhibiting oxidative stress.

A skin care composition and method for improving a patient's temporary post-treatment discomfort after a skin rejuvenation treatment and creating a healing-promoting environment to increase the likelihood that the patient will return for multiple treatments. The skin care composition includes an emulsion formed from active ingredients in a cosmetically acceptable carrier. The active ingredients include an effective amount of one or more neurobeautifying ingredients selected to increase the concentration of β-endorphin, decrease the concentration of CGRP, and block TRPV1 activity, and an effective amount of a prebiotic selected to nourish the native microbiome in human skin.

Chronic intractable pain is a global health issue, highlighting the need for a potent μ-agonist analgesic with minimal major side effects. Intrathecal administration of β-endorphin in humans produces significant analgesia without respiratory depression or tolerance. Earlier animal studies concluding that chronic administration of β-endorphin results in tolerance and respiratory depression may not be applicable to humans due to differences between human and animal μ-receptors and β-endorphins. It is anticipated that β-endorphin functions as a GPCR biased ligand, similar to ligand binding in endocrinopathies that do not usually produce tolerance. Ester prodrugs of β-endorphin are predicted to cross the human blood-brain barrier (BBB), undergo hydrolysis to β-endorphin and a non-toxic metabolite, and provide substantial analgesia with low toxicity and without major side effects. The synthesis of lead prodrugs is described. Compared to current pharmaceutical development expenditures, the risks associated with this research are considered low.

The invention relates to a natural essential oil composition for improving anxiety emotion, and belongs to the technical field of essential oil. The natural essential oil composition for improving anxiety mood disclosed by the invention is prepared from the following raw materials: camellia essential oil, lemon essential oil, jasmine flower essential oil, a white tea extract, cedarwood essential oil, guaiacol essential oil and southern magnolia flower essential oil. The lemon essential oil firstly gives out fresh lemon fruit fragrance, then the lemon essential oil is accompanied with camellia flower fragrance and jasmine flower fragrance to cause sensitivity and attention of olfaction, white tea fragrance serves as transition to enable the whole body to be in a relaxed state, and finally, light flower fragrance, fresh grass fragrance and light mud fragrance are doped in fragrance based on wood, so that the fragrance is more comfortable. The quiet, comfortable and natural feeling that the brain is associated with the body in the forest is easily triggered, and people are full of pleasure and happiness along with the reduction of cortisol and the increase of enkephalin. Therefore, the natural essential oil composition prepared by the invention has the effects of improving anxiety and enabling people to be in a pleasant and relaxed state.

Provided herein are piperidine dione compounds having the following structure:wherein RN, R1, R2, R3, R4, RN, L, V, X, a, m, and n are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

This invention belongs to the field of cosmetic composition technology, specifically relating to an essential oil composition with repairing and anti-aging effects and its application. The essential oil composition consists of carrot seed oil, white chamomile flower oil, and unsaponifiables from shea butter. This composition effectively promotes the release of endorphins from skin cells, helping to relieve skin stress; simultaneously, it significantly inhibits excessive cortisol secretion under stress, alleviating skin stress responses at their source. This composition exhibits excellent barrier repair capabilities, promoting keratinocyte migration and scratch healing, upregulating the expression of barrier-related genes, and effectively scavenging UV-induced reactive oxygen species, reducing oxidative damage. Furthermore, this composition significantly promotes the expression of type I and type III collagen, exerting repairing and anti-aging effects from multiple perspectives.

This invention relates to a topical skin extract, its preparation method, and its application, belonging to the field of plant extraction and cosmetic application technology. The invention provides a method for preparing a topical skin extract derived from "Hibiscus Ointment," an optimized version of a traditional Chinese and Western medicine formula for treating acute abdominal pain. The formula includes Hibiscus mutabilis leaves, rhubarb, Lycopus lucidus leaves, Phellodendron amurense, Coptis chinensis, Scutellaria baicalensis, and borneol. The resulting extract has a higher content of flavonoids, stronger anti-inflammatory and antioxidant capabilities, and is more stable. Furthermore, the combination of this extract and glycerol glucoside exhibits a synergistic effect in reducing skin inflammation and promoting the expression of barrier-related proteins and β-endorphins, thus simultaneously addressing the effects of endogenous and exogenous factors on the skin and improving skin condition.

The invention provides an application of schizophyllan in preparation of a nerve beautifying or emotion skin care product, and the schizophyllan can improve the generation of oxytocin and enorphin, so that the schizophyllan can be used in the nerve beautifying or emotion skin care product. The traditional Chinese medicine composition has the effects of regulating brain waves, increasing the pain threshold value of the skin, reducing external pressure, reducing skin sensitivity, relieving the tension state of the skin and improving the skin quality, and can reduce skin pain and pruritus, reduce external stimulation and pressure on the skin and improve the sensitive skin quality.