4 results about "Endorphins" patented technology

Chronic intractable pain is a global health issue, highlighting the need for a potent μ-agonist analgesic with minimal major side effects. Intrathecal administration of β-endorphin in humans produces significant analgesia without respiratory depression or tolerance. Earlier animal studies concluding that chronic administration of β-endorphin results in tolerance and respiratory depression may not be applicable to humans due to differences between human and animal μ-receptors and β-endorphins. It is anticipated that β-endorphin functions as a GPCR biased ligand, similar to ligand binding in endocrinopathies that do not usually produce tolerance. Ester prodrugs of β-endorphin are predicted to cross the human blood-brain barrier (BBB), undergo hydrolysis to β-endorphin and a non-toxic metabolite, and provide substantial analgesia with low toxicity and without major side effects. The synthesis of lead prodrugs is described. Compared to current pharmaceutical development expenditures, the risks associated with this research are considered low.

This invention belongs to the field of cosmetic composition technology, specifically relating to an essential oil composition with repairing and anti-aging effects and its application. The essential oil composition consists of carrot seed oil, white chamomile flower oil, and unsaponifiables from shea butter. This composition effectively promotes the release of endorphins from skin cells, helping to relieve skin stress; simultaneously, it significantly inhibits excessive cortisol secretion under stress, alleviating skin stress responses at their source. This composition exhibits excellent barrier repair capabilities, promoting keratinocyte migration and scratch healing, upregulating the expression of barrier-related genes, and effectively scavenging UV-induced reactive oxygen species, reducing oxidative damage. Furthermore, this composition significantly promotes the expression of type I and type III collagen, exerting repairing and anti-aging effects from multiple perspectives.

This invention relates to a topical skin extract, its preparation method, and its application, belonging to the field of plant extraction and cosmetic application technology. The invention provides a method for preparing a topical skin extract derived from "Hibiscus Ointment," an optimized version of a traditional Chinese and Western medicine formula for treating acute abdominal pain. The formula includes Hibiscus mutabilis leaves, rhubarb, Lycopus lucidus leaves, Phellodendron amurense, Coptis chinensis, Scutellaria baicalensis, and borneol. The resulting extract has a higher content of flavonoids, stronger anti-inflammatory and antioxidant capabilities, and is more stable. Furthermore, the combination of this extract and glycerol glucoside exhibits a synergistic effect in reducing skin inflammation and promoting the expression of barrier-related proteins and β-endorphins, thus simultaneously addressing the effects of endogenous and exogenous factors on the skin and improving skin condition.

The invention provides an application of schizophyllan in preparation of a nerve beautifying or emotion skin care product, and the schizophyllan can improve the generation of oxytocin and enorphin, so that the schizophyllan can be used in the nerve beautifying or emotion skin care product. The traditional Chinese medicine composition has the effects of regulating brain waves, increasing the pain threshold value of the skin, reducing external pressure, reducing skin sensitivity, relieving the tension state of the skin and improving the skin quality, and can reduce skin pain and pruritus, reduce external stimulation and pressure on the skin and improve the sensitive skin quality.