5 results about "Pyrazoline derivatives" patented technology

The present invention belongs to the field of pesticides and specifically relates to a substituted phenylpyrazoline derivative or a pesticide-acceptable salt thereof, a composition, and uses thereof. The compound has the structure of Formula (I): #imgabs0#, wherein the definitions of the various groups in the formula are as provided in the specification. The compounds of the present invention are based on the structure of a phenylpyrazoline derivative and incorporate a substituted pyrazole group, resulting in a class of compounds useful as herbicides and / or fungicides, exhibiting outstanding biological activity and crop safety.

The present invention belongs to the field of chemical analysis and detection technology, and provides a pyrazoline derivative lysosome-targeted biological thiol fluorescent probe and its preparation method and application. The preparation method of the pyrazoline derivative lysosome-targeted biological thiol fluorescent probe of the present invention comprises the following steps: mixing compound 1, 2-chloro-3,5-dinitropyridine, a base and an organic solvent and reacting to obtain a pyrazoline derivative lysosome-targeted biological thiol fluorescent probe. The fluorescent probe of the present invention can monitor the concentration fluctuations of Cys, Hcy and GSH in living cell lysosomes in real time by fluorescence imaging, and has the advantages of high selectivity, high sensitivity and rapid response; good selectivity and low cytotoxicity make it an ideal tool for simultaneous detection of Cys, Hcy and GSH.

The present application belongs to the field of heterogeneous catalytic preparation of energetic materials, and provides a method for preparing pyrazoline by internal cyclization of ketone hydrazine with ZSM-5 molecular sieve as catalyst. The preparation method is a heterogeneous reaction, which is used to improve the conversion efficiency of acetone hydrazine, solve the problem of difficult separation of catalyst and product, and avoid the technical problem of waste acid catalysis in traditional process. ZSM-5 molecular sieve is a kind of porous material with uniform pore channel, large specific surface area, good thermal stability, high product separation efficiency, easy to control the surface acidity and alkalinity, excellent catalytic selectivity and conversion rate. Compared with the traditional homogeneous acid catalysis of ketone hydrazine internal cyclization to prepare 2-pyrazoline derivatives, the ZSM-5 molecular sieve catalyst not only effectively catalyzes the reaction, but also reduces the post-treatment operation and effectively separates the product. The target product pyrazoline derivative is easy to form a ternary tension ring, which is a key precursor of new high-energy fuel, and has great potential in industrial application.

The invention relates to the technical field of biological medicine, in particular to a synthesis method of a 2-pyrazoline derivative. According to the invention, terminal alkyne, ketone and carbazate are used as reaction raw materials and react in an aprotic polar solvent in the presence of strong base to obtain the 2-pyrazoline derivative. The method has the advantages of low cost, simplicity and convenience in operation, short time, wide substrate application range and the like, 3, 4, 5-site substituents on a 2-pyrazoline mother nucleus ring can be freely adjusted according to the types of terminal alkyne and ketone, and various 2-pyrazoline derivatives can be conveniently prepared.

An N-formamidopyrazoline derivative is a compound having General Formula (I) or an enantiomer, a diastereomer, an epimer and a racemate thereof, or a pharmaceutically acceptable salt thereof. The compound is an antagonist of a ligand-gated non-selective cation channel receptor subtype P2X3, and can be used for treating or preventing various diseases mediated by the receptor P2X3.