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Direct immunity sensor and analyzing method

A device and detection chamber technology, which is applied in the field of devices for immunoassays, can solve the problems of producing biologically harmful waste liquid and complicating the assay process, and achieves the effect of simple and convenient manufacturing.

Inactive Publication Date: 2007-11-21
LIFESCAN INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Rinsing steps complicate the assay and generate biohazardous waste

Method used

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  • Direct immunity sensor and analyzing method
  • Direct immunity sensor and analyzing method
  • Direct immunity sensor and analyzing method

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Embodiment Construction

[0028] The following description and examples detail preferred embodiments of the invention. Those skilled in the art will recognize that many modifications and changes can be made within the scope of the invention. Therefore, the description of the preferred embodiment should not be taken as limiting the scope of the invention.

[0029] The sensor strip provided by the present invention contains two chambers: a reaction chamber and a detection chamber. The sample is accommodated in a reaction chamber where components of the sample undergo an immunoreaction. One or more products of the immune response are detected in the detection chamber to determine the amount of antigen present in the sample. The reaction chamber and the detection chamber are arranged so that the sample can flow from the reaction chamber into the detection chamber.

[0030] After the immunoreaction in the reaction chamber, at least some of the reacted sample is transported to the detection chamber, where t...

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Abstract

This invention describes a quantitative, inexpensive, disposable immunosensor that requires no wash steps and thus generates no liquid waste. Moreover, in preferred embodiments of the sensor no timing steps are required of the user, and the sensor can be readily adapted to antigen-antibody interactions over a wide kinetic range.

Description

technical field [0001] The present invention relates to a device and method for performing an immunoassay. The device consists of a single-use immunosensor. Background technique [0002] Biomedical sensors are used to report the presence and / or concentration of various analytes. If the analyte is a protein, the sensing element used is usually an antibody because antibodies interact very specifically with proteins (antigens). Such immunoassay techniques generally fall into two categories: those that can be performed by simple visual inspection to obtain a yes or no answer, and those that use quantitative methods to determine the concentration of antigen. Most quantitative methods require the use of expensive equipment, such as scintillation counters (used to monitor radioactivity), spectrophotometers, spectrofluorometers (see U.S. Patent U.S. 5,156,972), surface cytoplasmic gene resonance instruments (see U.S. Patent U.S. 5,965,456) and other instruments. Therefore, it is ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/53G01N33/543G01N33/68G01N27/26C12Q1/68C12Q1/00G01N27/327G01N27/333G01N27/416
CPCC12Q1/001G01N33/5438G01N33/53
Inventor A·霍奇斯R·查特利尔
Owner LIFESCAN INC