Novel process for synthesizing cyclohexyl formic acid by benzoic acid hydrogenation

Abstract

The novel process of hydrogenating benzoic acid to synthesize cyclohexyl formic acid includes the catalytic cyclization reaction of benzoic acid via contact with hydrogen inside supercritical CO2 and cyclohexyl formic acid without solvent in the presence of metal rhodium catalyst and under mild reaction condition; and subsequent extraction to separate product from the catalyst by means of the dissolubility of cyclohexyl formic acid in supercritical CO2. The technological process of the present invention has the advantages of mild reaction condition, clean reaction process, no side product and waste, no need of post-separation, and high product yield and quality.

Description

technical field

[0001] The invention relates to a method for synthesizing cyclohexyl formic acid by hydrogenation of benzoic acid, specifically: under solvent-free conditions, a supported rhodium catalyst in supercritical carbon dioxide and cyclohexyl formic acid catalyzes the method for synthesizing cyclohexyl formic acid by hydrogenating benzoic acid Background technique

[0002] Cyclohexylcarboxylic acid and its derivatives are important organic chemical raw materials and intermediates of synthetic drugs, and have a wide range of application prospects. Cyclohexyl carboxylic acid can be used in the synthesis of photocuring agent 184, namely: 1-hydroxycyclohexyl phenyl ketone; it is also an efficient UV curing initiator and non-yellowing photoinitiator, solubilizer for vulcanized rubber, and petroleum clarification Agents and pharmaceutical intermediates, etc. Cyclohexylcarboxylic acid can be prepared from benzoic acid catalytic hydrogenation, which is an important step in...