Red sage root ligustrazine freeze dried injecta and preparation method thereof

A technology of freeze-dried powder injection and ligustrazine, which is applied in the field of freeze-dried powder injection and its preparation for the treatment of cardiovascular and cerebrovascular diseases, and in the field of injection medicine and preparation. Treatment effect, production, storage, use hidden dangers and other issues, to achieve reliable curative effect, easy to shape, convenient application effect

Inactive Publication Date: 2008-01-16
CSPC OUYI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor stability of the liquid, it is easy to decompose over time to produce impurities, which will affect the quality and therapeutic effect of the drug, and cause certain hidden dangers to drug manufacturers and medical units in many links such as production, storage, and use.
In addition, the transportation, storage and carrying of liquid injections are inconvenient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0021] In the preparation method of the present invention, the extraction process of Salvia miltiorrhiza, including material selection, decoction, alcohol precipitation, etc., undergoes repeated comparison tests, repeated screening, finds out the best conditions, and formulates strict operating techniques one by one, so that the The content of Danshensu is high and there are few impurities, thus effectively improving product quality.

[0022] First, the selection of the origin of Salvia miltiorrhiza: Take 100g of Danshen medicinal materials from different origins, weigh them accurately, place them in a round bottom flask, add 12 times of distilled water respectively, reflux and extract for 2 hours, filter while hot, take 100ml of the filtrate, and use 10 % hydrochloric acid to adjust the pH value to 2.0, and then extracted once with 100 ml of ethyl acetate. The extract was concentrated to dryness, and the residue was dissolved in 100ml of methanol, used as the test solution, f...

Embodiment 1

[0045] Embodiment 1. Salvia miltiorrhiza (crude drug) 1000g, ligustrazine hydrochloride 110g, sorbitol 100g

Embodiment 2

[0046] Embodiment 2. Salvia miltiorrhiza (crude drug) 500g, ligustrazine hydrochloride 90g, sorbitol 50g, sodium citrate 50g

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PUM

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Abstract

The invention provides a red sage root ligustrazine freeze dried injecta and its preparation, wherein the injection is in powder form, and comprises red sage root extract, Chuangxiongzine Hydrochlorid and right amount of filling agent by the weight proportion of 400-1100:50-150:0-200, the preparing process comprises extracting red sage root liquid, configuring the soup, freeze drying and packaging.

Description

technical field [0001] The invention relates to a drug for injection and a preparation method thereof, in particular to a freeze-dried powder injection for treating cardiovascular and cerebrovascular diseases and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Salvia miltiorrhiza is a drug widely used clinically for promoting blood circulation and removing blood stasis. It has the functions of increasing coronary blood flow, lowering blood fat, inhibiting thrombosis or antithrombosis, and improving microcirculation. Ligustrazine is a typical calcium ion channel blocker, which has pharmacological characteristics such as inhibiting the production of free radicals, increasing the activity of endogenous SOD, scavenging oxygen free radicals, improving blood rheology, inhibiting platelet aggregation, and inhibiting fibrosis. It also has the effects of dilating blood vessels, increasing coronary blood flow, improving microci...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/53A61K31/4965A61K9/19A61P9/10A61P7/02
Inventor 魏淑辉高志峰郭卫芹韩卫占孙鹏智彩辉
Owner CSPC OUYI PHARM CO LTD
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