Usage of rhubarb root and its extractions in the process for preparing postprandial blood sugar decreasing medicine

A technology of rhubarb extract and postprandial blood sugar, which is used in the preparation of α-glucosidase inhibitor drugs, traditional Chinese medicine rhubarb and its extract in the field of preparing drugs for lowering postprandial blood sugar, can solve limited problems and have not yet seen application reports, etc. The problem is to achieve the effect of inhibiting α-glucosidase, the extraction and preparation method is simple and easy, and the drug source is sufficient.

Inactive Publication Date: 2008-02-27
CHENGDU DIAO PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the existing diabetes treatment drugs, sulfonylureas lower blood sugar by stimulating the secretion of insulin; biguanides lower blood sugar by increasing the utilization of glucose by peripheral tissues. Good curative effect, but very limited effect on lowering postprandial blood sugar
But there is no application report of rhubarb in the preparation of drugs with α-glucosidase inhibitory activity and drugs for reducing postprandial blood sugar

Method used

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  • Usage of rhubarb root and its extractions in the process for preparing postprandial blood sugar decreasing medicine
  • Usage of rhubarb root and its extractions in the process for preparing postprandial blood sugar decreasing medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 The preparation of rhubarb crude drug

[0023] Take the crude rhubarb of traditional Chinese medicine, that is, the dry root and rhizome of Rheum palmatum L., Rheum tanguticum Maxim ex Balf. or rhubarb officinale Baill. Sieve to make rhubarb fine powder with a particle size of 60-80 mesh, put the fine powder into capsules, sterilize, and pack separately.

Embodiment 2

[0024] The preparation of embodiment 2 rhubarb water extract, rhubarb ethanol extract

[0025] The traditional Chinese medicine rhubarb, that is, the dried root and rhizome of rhubarb palmatum (Rheum palmatum L.), Rheumtanguticum Maxim ex Balf. or medicinal rhubarb (Rheum officinale Baill.) are used as raw materials to remove impurities. Get 500 g of rhubarb crude drug, add 10 times the amount of water after pulverization, extract by heating and reflux for 2 hours, add ten times the amount of water to the filter residue, extract by heating and reflux for 2 hours, filter, combine the filtrate twice, and concentrate to obtain rhubarb water extract (hereinafter referred to as DH-1). Take another 1000g of rhubarb crude drug, crush it, add 10L of 70% ethanol solution, heat and reflux for extraction for 2 hours, add 6L of 70% ethanol solution to the filter residue, heat and reflux for extraction for 2 hours, filter, combine the two filtrates, and concentrate to obtain rhubarb ethano...

Embodiment 3

[0026] The preparation of embodiment 3 rhubarb extract

[0027]Take 200g rhubarb crude drug, crush it, impregnate twice with 1600ml of 95% and 30% ethanol respectively, each time for 12 hours, combine the impregnating solution, concentrate under reduced pressure to make extract, dissolve the extract in 2L distilled water, and take the supernatant , the supernatant flowed through the non-polar (D-140) and polar (D-160) macroporous adsorption resin columns in turn, and eluted the polar resin column with 3 times column volume of distilled water until the effluent was colorless, and then They were eluted with 75% and 25% ethanol respectively, and the eluate was collected, concentrated and dried under reduced pressure to obtain 630 mg of solid powder (hereinafter referred to as DH-3).

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Abstract

The invention provides the use of traditional Chinese medicinal rheum officinale and its extract in preparing medicament for reducing blood sugar. The original rheum officinale medicament, the water or organic solvent extract of rheum officinale can suppress the activity of alpha-glucosaccharase.

Description

technical field [0001] The invention relates to the new application of traditional Chinese medicine and its extract. Specifically, the invention relates to the application of traditional Chinese medicine rhubarb and its extract in the preparation of drugs for lowering postprandial blood sugar, which can be used to prepare α-glucosidase inhibitor drugs. Background technique [0002] For many years, the treatment of diabetes has mainly aimed at controlling fasting blood sugar, and the treatment drugs have long been mainly concentrated on sulfonylureas and biguanides. In recent years, studies have found that postprandial blood glucose is also a major risk factor for diabetic complications. Postprandial blood glucose is the highest level of blood glucose in a day in diabetes, and its duration can last for 8 hours or longer. Postprandial blood sugar can aggravate diabetes itself and further increase blood sugar. If high blood sugar can be well controlled during meals, the accumul...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/708A61K9/18A61K9/16A61K9/20A61K9/14A61K9/08A61K9/10A61P3/10A61K125/00
Inventor 高小平徐大勇邹文俊刘忠荣李伯刚
Owner CHENGDU DIAO PHARMA GROUP
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