Blood sugar regulator used during user having meals and its prepn. method

A regulator and blood sugar technology, applied in the direction of anti-toxic agents, medical preparations containing active ingredients, digestive system, etc., can solve the problems of high price and lack of market competitiveness, achieve good protective effect, good timing of taking medicine, and reduce production cost effect

Inactive Publication Date: 2007-04-18
王京杭
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the GXM prepared by this process is used for the mealtime blood sugar regulator of the present invention, the price is higher and lacks market competitiveness

Method used

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  • Blood sugar regulator used during user having meals and its prepn. method
  • Blood sugar regulator used during user having meals and its prepn. method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] GXM separation and purification

[0052] The commercially available Tremella fruit body (dry) is crushed into fine powder. Add tap water and Tremella powder in the reaction tank at a weight ratio of 20:1 (w / w), heat it to 140°C under stirring and maintain it for 3 hours, then stop heating. After cooling, vent gas, open the can, centrifuge to take the supernatant, add 4 times the volume of 95% edible ethanol to precipitate it under stirring, centrifuge to take the precipitate, add 10 times the weight of water to dissolve, centrifuge to take the supernatant ultrafiltration (intercept The molecular weight is 10KD) concentrate, repeat ultrafiltration and washing several times, spray-dry the concentrate to make GXM dry powder.

[0053] The process of preparing GXM from the fermentation broth of Tremella fuciformis can also refer to this method. Using different extraction temperature, time and pH value and other conditions to hydrolyze Tremella, GXM components wi...

Embodiment 2

[0058] Preparation of GXM granules

[0059] According to the prescription design requirements, mix the GXM dry powder that meets the quality standards with the sweetener powder (such as stevia) at a ratio of 100:1 (w / w), and then quantify the 5g GXM per bag into a composite aluminum foil bag. , After sealing, you can get meal blood glucose regulator products. If the original GXM granules are prepared, the sweeteners and other auxiliary materials may not be added. If preparing GXM multi-vitamin granules, you can add the required vitamins according to the prescription requirements.

[0060] The production process of the product should be carried out in accordance with the relevant national drug or food regulations. For professionals in the field of pharmaceutical or food production, the preparation process is a conventional technology.

Embodiment 3

[0062] The effect of GXM on blood glucose after meal in mice

[0063] Take 50 normal Kunming mice (male), weighing 20±2g / mouse. Randomly group, 10 animals in each group. The mice were fasted overnight (free drinking water), blood was collected from the tail the next day to measure fasting blood glucose (FBG), and then 0.40ml of food was given by gavage. The food of the control group is: 12.5% ​​(W / v) refined powder suspension (starch has been heated and gelatinized), the dose is equivalent to 2.5g / kg; the food composition of the GXM test group is: GXM + 12.5% ​​(W / v) refined powder. GXM has three types of high, medium and low molecular weight (HMW, MMW, LMW). Detect blood glucose 0.5, 1, 2 hours after gavage. The blood glucose monitor is SmartScan (produced by Johnson & Johnson, USA).

[0064] result:

[0065] Group

Molecular weight

Dose

Blood glucose level after meal (mmol / L)

AUC

Daltons

g / kg

0h

0.5h

1h

2h

...

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PUM

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Abstract

A blood sugar regulator applied on dining, a process for preparing lignomannosan gluconate, and its application in regulating blood sugar, decreasing blood sugar and blood fat, losing weight and preventing ulcer and constipation are disclosed.

Description

Invention field [0001] The invention relates to a meal blood sugar regulator with glucomannan glucomannan as an effective ingredient and its use in the field of diabetes prevention and health care, as well as a preparation process and its use of glucomannan glucomannan. Background technique [0002] Diabetes (Diabetes Mellitus, DM) is a chronic endocrine and metabolic disease caused by a lack or relative lack of insulin in the human body. It is characterized by glucose metabolism disorders, and is mainly characterized by high blood sugar in the untreated state, and is accompanied by Abnormal protein and fat metabolism. Uncontrolled hyperglycemia is the main factor leading to a series of complications in diabetic patients. It not only brings great pain to patients, severely declines the quality of life, and even life-threatening, but also brings a heavy economic burden to the society. Diabetes has a high incidence and great harm, and patients often need to take medicine for life. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P3/04A61P3/06A61P3/10A61P1/04A61P1/10A61P11/00A61P17/16A61P35/00A61P37/02A61P39/06
Inventor 王京杭
Owner 王京杭
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