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Dripping pills of rheocamphoradin and its preparation process

A technology of water drop pills and camphor, which is applied in the direction of pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems that are not conducive to improving the ability of patients to seek medical treatment, low dissolution rate, long dissolution time limit, etc., to improve biological Effectiveness of availability, acceleration of dissolution and absorption, and improvement of ability to seek medical treatment

Inactive Publication Date: 2008-03-19
广西宝瑞坦广明制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking. , thus affecting the efficacy of the drug and directly affecting the therapeutic effect
Although the soft capsule also has the advantage of high bioavailability, due to the influence of its coating material, when the storage time reaches more than half a year, it is prone to aging phenomenon, so that the coating material cannot be dissolved well after entering the stomach and produces residue
[0008] In addition, conventional oral dosage forms, such as tablets, capsules, granules (infusions), etc., due to the granulation process in the preparation process, will generate relatively large dust pollution, which will cause health problems to the staff to a certain extent. harm, and also cause some pollution to the environment
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0031] Now with several groups of specific examples, the preparation method of the ten drops of water dripping pills of the present invention will be further described.

[0032] [Group 1: Trials with a single substrate]

[0033] 1. Raw materials: According to the [Appendix], the extract dry powder containing active pharmaceutical ingredients of 7 traditional Chinese medicines, such as camphor, dried ginger, rhubarb, fennel, cinnamon, pepper, and eucalyptus oil, was first prepared for use;

[0034] 2. Substrate: polyethylene glycol 1000 , polyethylene glycol 4000 , polyethylene glycol 6000 , polyethylene glycol 10000 , Macrogol 20000, Span 40, Polyoxyl 40 Stearate, Poloxamer, Sodium Lauryl Sulfate, Stearic Acid, Sodium Stearate, Glycerin Gelatin, Shellac;

[0035] 3. Proportion: take g or kg as the unit, by weight, drug extract: matrix = 1:1~1:9:

[0036] 4. Prepare according to the process given in [Preparation Method] 4-7, and then Shidishui droplet pills of different sp...

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PUM

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Abstract

Disclosed is a dripping pill for treating dizziness, nausea, abdominalgia and stomach malaise. The objective of the invention is to provide a medicinal composition having the advantages of high biological availability, quick-speed medicine release, quick-speed effect, higher medicinal content, accurate quantitative determination, easy administration, low price, and causing no pollution during production. The drop pill is prepared from camphor, dried ginger, rhubarb horsetails, common fennel fruit, Cinnamomum cassia, pepper, eucalyptus oil, and medicinal carrying agent as the base material.

Description

technical field [0001] The present invention relates to a kind of medicinal composition with invigorating stomach and carminative effect, which is used for the treatment of dizziness, nausea, abdominal pain, gastrointestinal discomfort and other diseases caused by heat stroke. An oral preparation of a pharmaceutical composition prepared from the extracts of 7 traditional Chinese medicine active ingredients such as cinnamon, cinnamon, pepper, and eucalyptus oil as raw materials. Background technique [0002] According to the preparation method given under Shidishui on page 301 of the Pharmacopoeia of the People's Republic of China in 2005, Shidishui is a kind of medicine that has the functions of invigorating the stomach and dispelling wind, and is used for dizziness, nausea, Oral liquid preparations for the treatment of abdominal pain, gastrointestinal discomfort and other diseases have been clinically verified for many years and have definite curative effects. They are comm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/9068A61K36/81A61K36/708A61K36/61A61K36/54A61K36/23A61P1/08
Inventor 梁宁生曲韵智
Owner 广西宝瑞坦广明制药有限公司