Method of improving anti collapsibility of calcium phosphate skeletal cement using denaturated starch

A technology of calcium phosphate bone cement and modified starch, applied in medical science, prosthesis and other directions, can solve the problems of delaying the curing time of calcium phosphate bone cement, reducing the strength of the implant, and collapsing, so as to improve the anti-collapse performance, improve the Rheological properties, effect of improving collapse resistance

Active Publication Date: 2008-06-04
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
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Problems solved by technology

[0006] The purpose of the present invention is to overcome the deficiencies in the prior art of calcium phosphate bone cement that will collapse when soaked and washed by body fluids before self-curing and that the existing anti-collapse agent will delay the curing time of calcium phosphate bone cement and reduce the strength of the implant To provide a method to improve the anti-collapse performance of calcium phosphate bone cement by applying modified starch to meet the requirements of surgical use, so as to expand the new medical value of modified starch, and at the same time make calcium phosphate bone cement have a broader application prospect

Method used

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  • Method of improving anti collapsibility of calcium phosphate skeletal cement using denaturated starch
  • Method of improving anti collapsibility of calcium phosphate skeletal cement using denaturated starch
  • Method of improving anti collapsibility of calcium phosphate skeletal cement using denaturated starch

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Embodiment 1

[0027] The method for improving the anti-collapse performance of calcium phosphate bone cement by applying pregelatinized cornstarch (commercial, Guangzhou Si Debao Flavor and Fragrance Co., Ltd.) comprises the following steps:

[0028] (1) Preparation of calcium phosphate bone cement solidification solution:

[0029] Add 0.1 g of pre-gelatinized corn starch into 20 ml of deionized water, heat in a water bath at 100° C. for 2 minutes, and prepare a solidified solution containing 0.5% of pre-gelatinized corn starch.

[0030] (2) Preparation of calcium phosphate bone cement material solidified body for bone injury repair:

[0031] Mix the bone cement powder of tetracalcium phosphate and calcium hydrogen phosphate system with the solidified solution obtained in step (1) at a liquid-solid ratio of 0.4ml / g, and then inject the bone cement paste into the mold for molding. The obtained bone cement molded body is placed in a simulated human body environment and cured for more than 24...

Embodiment 2

[0038] Application of sweet potato starch phosphate (laboratory system, preparation method refers to "Optimization of Preparation Conditions of Sweet Potato Starch Phosphate Monoester" Chen Ling, etc., Journal of Zhengzhou Institute of Technology, 2004 (1)) to improve the method of calcium phosphate bone cement anti-collapse performance, including Follow the steps below:

[0039] (1) Preparation of calcium phosphate bone cement solidification solution:

[0040] Add 0.2 g of phosphated sweet potato starch into 20 ml of sodium hydrogen phosphate solution, heat in a water bath at 100°C for 2 minutes, and then prepare a solidified solution containing 1% phosphated sweet potato starch.

[0041] (2) Preparation of calcium phosphate bone cement material solidified body for bone injury repair:

[0042] Mix calcium dihydrogen phosphate-α-tricalcium phosphate-calcium carbonate system bone cement powder with the solidified liquid obtained in step (1) at a liquid-solid ratio of 0.4ml / g, ...

Embodiment 3

[0048] The method for improving the anti-collapse performance of calcium phosphate bone cement by applying tapioca starch acetate (commercial, Guangxi Mingyang Biochemical Technology Co., Ltd.) comprises the following steps:

[0049] (1) Preparation of calcium phosphate bone cement solidification solution:

[0050] Add 0.04 g of acetate tapioca starch into 20 ml of potassium hydrogen phosphate solution, heat in a water bath at 100° C. for 2 minutes, and then prepare a solidified solution containing 0.2% acetate tapioca starch.

[0051] (2) Preparation of calcium phosphate bone cement material solidified body for bone injury repair:

[0052] Mix the bone cement powder of tetracalcium phosphate and α-tricalcium phosphate system with the solidified liquid obtained in step (1) according to the liquid-solid ratio of 0.5ml / g, and then inject it into the mold for molding. Then the bone cement molded body is placed in a simulated human body environment for curing for more than 24 hou...

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Abstract

A method for improving the resistance of calcium phosphate type bone cement to collapse by using modified starch includes such steps as proportionally mixing the modified starch with deionized water or ionized liquid, mixing with said bone cement, stirring to become paste, and transplanting it in human body directly or after molding and solidifying.

Description

technical field [0001] The invention belongs to the field of medical materials for repairing bone damage, and relates to a new application of modified starch in improving the anti-collapse performance of calcium phosphate bone cement. Background technique [0002] Calcium phosphate bone cement is composed of powder mixed with one or more calcium phosphate salts and a solidifying solution. When used, the two are mixed in a certain proportion, and can be cured and molded accurately at room temperature or in the environment of the human body. Its hydration components are finally It is mainly transformed into hydroxyapatite (HA), which can guide bone growth, be gradually absorbed by tissue and produce bone tissue regeneration effect, has good biocompatibility, and currently shows great clinical application advantages and advantages in bone injury repair. It has a broad market prospect, but the material still has shortcomings, especially when it is soaked and washed by body fluid...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/12
Inventor 陈玲向弘叶建东李晓玺李琳
Owner SOUTH CHINA UNIV OF TECH
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