Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation technology of crataegus total phenolic acid portion and application

A technology of total phenolic acid and hawthorn, which is applied in the field of medicine, can solve the problems of activity decline and other problems, and achieve the effect of low cost, cheap price and sufficient source of raw materials

Inactive Publication Date: 2008-10-01
上海永恒生物科技有限公司
View PDF3 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, it is believed that the total flavonoids in hawthorn play a pharmacological role, and there are also some patents on the separation and extraction of total flavonoids in hawthorn (such as application number: 01103986.8 and application number: 01118628.3), but we have found through research that when the hawthorn After the flavonoid content in the total flavonoid extract is further increased, the activity decreases instead

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation technology of crataegus total phenolic acid portion and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: Preparation of effective part

[0037] Take 100kg of dried hawthorn leaves, grind them into coarse powder, and extract with 10 times the amount of 60% ethanol under reflux for three times, combine the extracts, concentrate under reduced pressure to 50L, place for precipitation, centrifuge, and pass the supernatant through AB-8 macroporous adsorption resin Chromatography, the water eluted part adjusted the pH value to 1, extracted with ethyl acetate, the extract was concentrated under reduced pressure, dissolved in water, and then chromatographed by AB-8 macroporous adsorption resin, eluted with water until the pH value was 3 to 5, continue to elute with 60% diacetone, concentrate the eluent under reduced pressure, and spray dry to obtain 0.52 kg of light yellow powder, which is the total phenolic acid fraction of hawthorn (the yield is 0.52% based on the crude drug amount). Through assay, the purity is 84.79%.

Embodiment 2

[0038] Embodiment 2: Preparation of effective fraction

[0039] Take 100 kg of dried hawthorn fruit, crush it, and extract it by percolation with 20 times the amount of 80% methanol, combine the percolation solution, concentrate it under reduced pressure to 50 L, place it for precipitation, centrifuge, and the supernatant is subjected to D101 macroporous adsorption resin chromatography, water After adjusting the pH value of the eluted part to 2, extract it with ethyl acetate, concentrate the extract under reduced pressure and dissolve it in water, then go through AB-8 macroporous adsorption resin chromatography, and elute with water until the pH value is 3-5. Continue to elute with 20% dilute ethanol, concentrate the eluate under reduced pressure, and spray dry to obtain 0.42 kg of light yellow powder, which is the total phenolic acid fraction of hawthorn (the yield is 0.42% based on crude drug amount). Through content determination, the purity is 67.25%.

Embodiment 3

[0040] Embodiment three: the preparation of tablet

[0041] Take 100g of the part of the present invention, 80g of starch, and 5g of dextrin and mix evenly, add 10% starch slurry to make soft material, granulate with a 14-mesh nylon screen, ventilate and dry at 60-70°C, granulate with a 16-mesh sieve, add stearic acid 1.5g of magnesium and 5g of sodium carboxymethyl starch were mixed evenly, pressed into 1000 tablets, and coated. Each tablet contains 100 mg of the site of the present invention. Adults take 2 to 5 times a day, 1 to 10 tablets each time.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A crab phenolic acid extracted from the leaf and fruit of crab can be used to prepare the medicine in the form of injection, or the orally taken forms for preventing and treating ischemic cardiovascular and cerebrovascular diseases, senile dementia and hyperlipemia. Its preparing process is also disclosed.

Description

Technical field: [0001] The invention belongs to the field of medicine, in particular to the preparation process and preparation of the total phenolic acid parts isolated from hawthorn leaves or fruits and its potential application in medicine and health food. Background technique: [0002] Cardiovascular and cerebrovascular diseases are one of the diseases with higher incidence in the world. With the development of social economy and the improvement of people's living standards, the prevalence of cardiovascular and cerebrovascular diseases is also increasing year by year. According to relevant reports, in 2001, 56 million people died in the world. The two leading causes, coronary heart disease and stroke, are responsible for 7 million and 5.5 million deaths, respectively. Because of this, countries all over the world attach great importance to the research and prevention of cardiovascular and cerebrovascular diseases. But so far, although there are many cardiovascular an...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/734A61K9/20A61K9/08A61K9/10A61K9/14A61P9/00A61P9/10A61P3/06C07B63/00
Inventor 张蓉
Owner 上海永恒生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com