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Production method of erigeron breviscopus element drop

A technology for breviscapine and a production method, which is applied in the directions of pill delivery, pharmaceutical formulations, cardiovascular system diseases, etc., can solve the problems of increased interfacial tension, small interfacial tension, and increased contact area, and can control the roundness of pellets. The effect of improving the qualified product rate and controlling the difference of pill weight

Active Publication Date: 2008-10-08
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The present invention aims at the problems existing in the dripping head of the current dripping machine, and adopts a diameter-limited cylindrical concave nozzle dripping head to increase the contact area between the liquid medicine drop and the dripping nozzle, increase the interfacial tension, and overcome the current dripping pills. The small contact area between the dropper nozzle and the droplet of the cylindrical plane nozzle used in the machine, and the small interfacial tension lead to the problem of the difference in pellet weight and the difficulty in controlling the roundness of pellets, which can improve the rate of qualified products and reduce the weight of pellets. Dosage

Method used

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  • Production method of erigeron breviscopus element drop
  • Production method of erigeron breviscopus element drop
  • Production method of erigeron breviscopus element drop

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take 1 part by weight of scutellarin fine powder crushed through a 100-mesh sieve, add it to the matrix where 1-4 parts by weight of polyethylene glycol 6000 and 2-5 parts by weight of polyethylene glycol 4000 are mixed and melted, stir well, and make a uniform The medicinal liquid is prepared by dripping with a diameter-limited cylindrical concave nozzle dropper under the condition of 75°C-85°C heat preservation, and cooled with 40°C-0°C dimethyl silicone oil, and the oil pellets are separated. Dry for 60 minutes under the conditions of 40°C and 55% relative humidity, sieve and select pellets, test, and pack to get final product.

[0023] Compared with the cylindrical plane nozzle dripper, the difference in pellet weight and qualified product rate of pellet roundness produced by the invention are increased by 30%. The dissolution rate of the product of the present invention is 95.3%.

Embodiment 2

[0025] Take 1 part by weight of breviscapine fine powder crushed through a 100-mesh sieve and add it to 2-6 parts by weight of molten polyethylene glycol 6000 matrix, stir well to make a uniform medicinal solution, and heat it at 80°C-90°C Next, use the diameter-limited cylindrical concave nozzle dropper method to drip, use 35°C to 5°C dimethyl silicone oil to gradually cool, and separate the oil pellets, under the conditions of a temperature of 45°C and a relative humidity of 50%. Dry for 30 minutes, sieve the pills to select the pills, inspect and pack, and the product is obtained.

[0026] Compared with the cylindrical planar nozzle dripper, the difference in pellet weight and qualified product rate of pellet roundness produced by the invention are increased by 21%. The dissolution rate of the product of the present invention is 96.1%.

Embodiment 3

[0028] Take 1 part by weight of scutellarin fine powder crushed through a 100-mesh sieve and add to 1-5 parts by weight of polyethylene glycol 6000, 2-4 parts by weight of polyethylene glycol 4000 and 0.1-3 parts by weight of sodium lauryl sulfate Mix and melt the matrix, stir well to make a uniform drug solution, drop it with a diameter-limited cylindrical concave nozzle dropper dripping method under the condition of 75 ° C ~ 90 ° C heat preservation, use 40 ° C ~ 5 ° C dimethicone The base silicone oil is gradually cooled, the oil pellets are separated, dried for 60 minutes at a temperature of 40°C and a relative humidity of 60%, the pellets are sieved, inspected, and packaged separately to obtain the product.

[0029] Compared with the cylindrical plane nozzle dropper, the difference in pellet weight and qualified product rate of pellet roundness produced by the invention are increased by 35%. The dissolution rate of the product of the present invention is 98.4%.

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Abstract

The invention adopts the limited diameter circular cylinder with concave canal orifice emitter dropping preparation method to produce breviscapine dropping pills which has better rate of qualified products in pills weight and pills roundness degree than that produced by the current production method using circular cylinder with plane canal orifice emitter, the dissolution rate of the pills is obviously increased compared with the market-selling breviscapine tablet, breviscapine dropping pills weighed ranging 30mg-100mg can also be produced using the present invention.

Description

technical field [0001] The invention relates to a production method of scutellarin dripping pills, which is characterized in that the scutellarin dripping pills are produced by adopting a diameter-limited cylindrical concave nozzle dripper dropping method. Background technique [0002] Cardiovascular and cerebrovascular diseases rank first among major diseases and seriously endanger human health. The sequelae caused also bring great pain to patients and their families, and become a social problem worthy of widespread attention. Medical workers from all over the world continue to research and develop drugs for the treatment of cardiovascular and cerebrovascular diseases, especially drugs for the prevention and rehabilitation of cardiovascular and cerebrovascular diseases, so that patients with cardiovascular and cerebrovascular diseases can be effectively treated. Therefore, the research and development of therapeutic drugs for cardiovascular and cerebrovascular diseases not ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/7048A61P9/10A61J3/06
Inventor 钱进陶琳穆正义刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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