Method for prodn. of dripping pills of andrographolide

A technology of andrographolide and its production method, which is applied in the direction of pill delivery, pharmaceutical formula, organic active ingredients, etc., can solve the problems of increasing interfacial tension, increasing contact area, small interfacial tension, etc., and achieves the control of roundness of pellets , Control the difference in pellet weight and improve the rate of qualified products

Active Publication Date: 2008-09-10
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The present invention aims at the problems existing in the dripping head of the current dripping machine, and adopts a diameter-limited cylindrical concave nozzle dripping head to increase the contact area between the liquid medicine drop and the dripping nozzle, increase the interfacial tension, and overcome the current dripping pills. The small contact area between the dropper nozzle and the droplet of the cylindrical flat nozzle used in the machine, and the small interfacial tension lead to the problem of the difference in pellet weight and the difficulty in controlling the roundness of pellets, which improves the rate of qualified products and can also increase the reduction in pellet weight. Dosage

Method used

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  • Method for prodn. of dripping pills of andrographolide
  • Method for prodn. of dripping pills of andrographolide
  • Method for prodn. of dripping pills of andrographolide

Examples

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Effect test

Embodiment 1

[0019] Take 1 part by weight of andrographolide crushed through a 100-mesh sieve, add it to 3-5 parts by weight of molten polyethylene glycol 6000 matrix, stir well to make a uniform liquid medicine, and use it under the condition of 80°C-95°C The diameter-limited cylindrical concave nozzle dropper dripping method is used for dripping, cooling with 35°C ~ 0°C dimethyl silicone oil, separating the oil pellets, and drying for 60 at a humidity of 40°C and a relative humidity of 50%. Minutes, sieve pills, select pills, test, pack, and get it.

[0020] Compared with the cylindrical plane nozzle dripper, the difference in pellet weight and qualified product rate of pellet roundness produced by the invention are increased by 36%.

[0021] Get sample, take 10% ethanol solution 1000ml as stripping medium, rotating speed is 100 revolutions per minute, operate according to dissolution assay (Chinese Pharmacopoeia version two appendix X C second method in 2005), during 45 minutes, get sol...

Embodiment 2

[0023] Take 1 part by weight of andrographolide crushed through a 100-mesh sieve, add it to a matrix in which 2-5 parts by weight of molten polyethylene glycol 6000 and 1-3 parts by weight of polyethylene glycol 4000 are mixed and melted, stir well, and make a uniform The medicinal solution is prepared by dripping with a diameter-limited cylindrical concave nozzle dripper at a temperature of 70°C to 90°C, cooled with simethicone oil at 45°C to 5°C, and the oil pellets are separated. Dry for 30 minutes under the conditions of 30°C and 55% relative humidity, sieve and select pellets, inspect, and pack separately to obtain final product.

[0024] Compared with the cylindrical plane nozzle dripper, the product pellet weight difference and pellet roundness qualified product rate of the product produced by the invention are increased by 29%.

[0025] Get sample, take 10% ethanol solution 1000ml as stripping medium, rotating speed is 100 revolutions per minute, operate according to d...

Embodiment 3

[0027] Take 1 part by weight of andrographolide crushed through a 100-mesh sieve and add to 2-6 parts by weight of molten polyethylene glycol 6000, 1-3 parts by weight of polyethylene glycol 4000 and 0.1-3 parts by weight of sodium lauryl sulfate Mix and melt the matrix, stir well to make a uniform drug solution, drop it with a diameter-limited cylindrical concave nozzle dropper dripping method under the condition of 75 ° C ~ 95 ° C heat preservation, use 40 ° C ~ 5 ° C dimethicone The base silicone oil is gradually cooled, the oil pellets are separated, dried for 60 minutes at a temperature of 35°C and a relative humidity of 45%, the pellets are sieved, inspected, and packaged separately to obtain the product.

[0028] Compared with the cylindrical plane nozzle dripper, the difference in pellet weight and qualified product rate of pellet roundness produced by the invention are increased by 36%.

[0029]Get sample, take 10% ethanol solution 1000ml as stripping medium, rotating...

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Abstract

A dripping pill of andrographolide with high solubility is prepared by use of the diameter limited cylindrical concave tube for high uniformity and roundness.

Description

technical field [0001] The invention relates to a production method of andrographolide dropping pills, which is characterized in that it adopts a diameter-limited cylindrical concave nozzle dropper dropping method to produce andrographolide dropping pills. Background technique [0002] Andrographolide is a diterpene lactone compound extracted from Andrographis paniculata (Andrographis Paniculata (Burm.f) Nees), which is one of the main active ingredients of traditional Chinese medicine Andrographis paniculata. And so on. The results of pharmacological studies show that andrographolide has a certain antipyretic effect on rabbits with fever caused by typhoid and paratyphoid bacteria or rats with fever caused by 2,4-dinitrophenol, and has a certain antipyretic effect on simultaneous infection with pneumococcus and hemolysis. Rabbits with fever caused by cultures of streptococcus can delay the rise time of body temperature and weaken the degree of rise of body temperature. It ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/365
Inventor 钱进陶琳穆正义刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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