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Method for producing medicine Yigan dipping-pills for tonifying liver

A technology of silymarin and its production method, which is applied in the fields of pill delivery, pharmaceutical formula, plant raw materials, etc., can solve the problems of increased interfacial tension, difference in pill weight, small interfacial tension, etc., and achieve control of pill roundness and pill weight Differences and the effect of improving the rate of qualified products

Active Publication Date: 2008-08-13
HONGYI SCI & TECH CO LTD NANCHANG
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The present invention aims at the problems existing in the dripping head of the current dripping machine, and adopts a diameter-limited cylindrical concave nozzle dripping head to increase the contact area between the liquid medicine drop and the dripping nozzle, increase the interfacial tension, and overcome the current dripping pills. The small contact area between the dropper nozzle and the droplet of the cylindrical plane nozzle used in the machine, and the small interfacial tension lead to the problem of the difference in pellet weight and the difficulty in controlling the roundness of pellets, which can improve the rate of qualified products and reduce the weight of pellets. Dosage

Method used

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  • Method for producing medicine Yigan dipping-pills for tonifying liver

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Experimental program
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Effect test

Embodiment 1

[0018] Take 1 part by weight of silymarin and add it to 4-10 parts by weight of molten polyethylene glycol 6000 matrix, stir well to make a uniform drug solution, and use a diameter-limited cylindrical concave nozzle under the condition of heat preservation at 80°C-90°C Drip drip method, cooling with simethicone oil at 40°C-5°C, separating the oil pellets, drying for 60 minutes at a temperature of 35°C and a relative humidity of 55%, screening the pellets, and testing , sub-package, that is.

[0019] Compared with the cylindrical flat spout dripper, the product pellet weight difference and pellet roundness qualified product rate of the product produced by the present invention are improved by 39%, and the dissolution time is 3 minutes, while the commercially available Yiganling (silymarin) sheet dissolves and disperses The time is 46 minutes, and the dissolution time of Yiganling (silymarin) capsule is 57 minutes.

Embodiment 2

[0021] Take 1 part by weight of silymarin and add it to the mixed and melted matrix of 4-6 parts by weight of polyethylene glycol 6000 and 2-4 parts by weight of polyethylene glycol 4000, stir well to make a uniform medicinal solution, and heat it at 75°C-90°C Under the condition of heat preservation, it is dripped with a diameter-limited cylindrical concave nozzle dropper, cooled with 45 ° C ~ 0 ° C dimethyl silicone oil, and the oil pellets are separated. The temperature is 30 ° C and the relative humidity is 50%. Dry for 30 minutes under the same conditions, sieve the pills to select the pills, inspect and pack them separately, and the product is obtained.

[0022] Compared with the cylindrical flat spout dripper, the product pellet weight difference and pellet roundness qualified product rate of the product produced by the present invention are improved by 42%, and the dissolving time is 6 minutes, while the commercially available Yiganling (silymarin) sheet dissolves and d...

Embodiment 3

[0024] Take 1 part by weight of silymarin and add it to the matrix in which 3-5 parts by weight of molten polyethylene glycol 6000, 1-3 parts by weight of polyethylene glycol 4000 and 0.2-3 parts by weight of sodium lauryl sulfate are mixed and melted, and stir well , to make a uniform drug solution, drop it with a cylindrical concave nozzle dropper with a limited diameter under the condition of 75 ° C to 95 ° C, and use 40 ° C to 10 ° C dimethyl silicone oil to cool it, and the oil pellets Separation, drying at a temperature of 35°C and a relative humidity of 40% for 60 minutes, sieving and selecting pellets, inspection, and subpackaging to obtain the product.

[0025] Compared with the cylindrical flat spout dropper, the weight difference of the product produced by the present invention and the qualified product rate of the roundness of the pellets are increased by 33%, and the dissolution time is 4 minutes, while the commercially available Yiganling (silymarin) sheet dissolv...

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Abstract

A process for preparing the 'Yiganling dripping pill' features that a diameter limited cylindrical dripping head with a concave mouth is used for higher uniformity and roundness of dripping pills.

Description

technical field [0001] The invention relates to a production method of silymarin dripping pills, which is characterized in that it is a method for producing silymarin dripping pills by adopting a diameter-limited cylindrical concave nozzle dropper dripping method. Background technique [0002] The main component of silymarin dripping pills is silymarin, which is an insoluble flavonoid compound extracted from the fruit of Silybum marianum L., a plant of Compositae. Silymarin was discovered by German pharmacists represented by H. Wagner in the late 1960s. Silymarin is composed of three isomers of silybin, silibinin, silidianin and silichristin. There is another isomer of silybin, called isosilybin, isosilibinin. The molecular formula of these isomers is C 25 h 22 o 10 , The molecular weight is about 482. Silybin is composed of 1 molecule of taxifolin (a flavonoid component) and 1 molecule of coniferyl alcohol (a lignan component). Therefore, silymarin is also named as f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/357A61K36/28A61J3/06A61P1/16A61P31/14A61P31/20
Inventor 穆正义钱进陶琳刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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