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Production process of five-ester droplet

A production method and technology for ester dropping pills, applied in the production field of pentaester dropping pills, can solve the problems of increasing interfacial tension, difference in pellet weight, small interfacial tension, etc., and achieve control of pellet roundness, control of pellet weight difference and , The effect of improving the rate of qualified products

Active Publication Date: 2009-09-02
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention aims at the problems existing in the dripping head of the current dripping machine, and adopts a diameter-limited cylindrical concave nozzle dripping head to increase the contact area between the liquid medicine drop and the dripping nozzle, increase the interfacial tension, and overcome the current dripping pills. The small contact area between the dropper nozzle and the droplet of the cylindrical flat nozzle used in the machine, and the small interfacial tension lead to the problem of the difference in pellet weight and the difficulty in controlling the roundness of pellets, which improves the rate of qualified products and can also increase the reduction in pellet weight. Dosage

Method used

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  • Production process of five-ester droplet

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Experimental program
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Effect test

Embodiment 1

[0014] Take 1 part by weight of Schisandra Alcohol Extract and add it to the mixed and melted matrix of 2-5 parts by weight of polyethylene glycol 6000 and 1-4 parts by weight of polyethylene glycol 4000, stir well to make a uniform medicinal solution. Under the condition of heat preservation at ℃, use the dripping method of the diameter-limited cylindrical concave nozzle dripper, and gradually cool with 35℃~0℃ dimethyl silicone oil, and separate the oil pellets, at a temperature of 30℃ and a relative humidity of 50%. Dry for 60 minutes under certain conditions, sieve the pills to select the pills, inspect, pack, and obtain.

[0015] Compared with the cylindrical plane nozzle dripper, the difference in pellet weight and qualified product rate of pellet roundness produced by the invention are increased by 27%.

Embodiment 2

[0017] Take 1 part by weight of Schisandra chinensis alcohol extract and add it to 2-6 parts by weight of molten polyethylene glycol 6000 matrix, stir well to make a uniform liquid, and use a diameter-limited cylindrical concave tube under the condition of 90 ° C heat preservation Oral dripping method, cooling with 35°C-5°C dimethyl silicone oil, separating the oil pellets, drying for 30 minutes at a temperature of 30°C and a relative humidity of 50%, and screening the pellets. Inspection, packaging, that is.

[0018] Compared with the cylindrical plane nozzle dripper, the difference in pellet weight and qualified product rate of pellet roundness produced by the invention are increased by 36%.

Embodiment 3

[0020] Take 1 part by weight of Schisandra Alcohol Extract and add it to the mixed and molten matrix of 1-3 parts by weight of polyethylene glycol 6000, 2-6 parts by weight of polyethylene glycol 4000 and 0.1-3 parts by weight of sodium lauryl sulfate, Stir well to make a uniform drug solution, drip it with a cylindrical concave nozzle dropper with a limited diameter at 75°C, cool it with 35°C-5°C dimethyl silicone oil, and separate the oil pellets , dried for 60 minutes under the conditions of a temperature of 30° C. and a relative humidity of 55%, sieving and selecting pellets, inspecting, and subpackaging to obtain the product.

[0021] Compared with the cylindrical plane nozzle dripper, the difference in pellet weight and qualified product rate of pellet roundness produced by the invention are increased by 33%.

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Abstract

The invention adopts the limited diameter circular cylinder with concave canal orifice emitter dropping preparation method to produce five-ester dropping pills which has better rate of qualified products in pills weight and pills roundness degree than that produced by the current production method using circular cylinder with plane canal orifice emitter, what is more, five-ester dropping pills weighed ranging 30mg-100mg can also be produced using the present invention.

Description

technical field [0001] The invention relates to a method for producing five-ester dripping pills, which is characterized in that the five-ester dripping pills are produced by using a diameter-limited cylindrical concave nozzle dripper dropping method. Background technique [0002] The main component of Wuzhi Dropping Pills is Schisandra Alcohol Extract, which can reduce serum aminotransferase. The results of years of clinical application have shown that it is safe and effective for patients with chronic and persistent hepatitis with elevated alanine aminotransferase. [0003] Currently, Wuzhi Capsules are widely used clinically, but due to their long disintegration and dissolution time, poor stability, bed rest, difficulty swallowing, and inconvenient medication for elderly patients, etc., the full play of its curative effect is affected. [0004] The five ester dripping pills not only have simple production process and production conditions, convenient operation, few proced...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/57A61K31/045A61K9/20A61P1/16A61P31/14A61J3/06
Inventor 穆正义钱进陶琳刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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