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Liver protection drip pill and its preparation method

A technology for protecting liver dripping pills and dripping pill machine, which is applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc. Physical hazards and other problems, to achieve the effect of improving bioavailability, drug safety, and low labor intensity

Inactive Publication Date: 2008-10-22
北京伟力康源医药科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking. , thus affecting the efficacy of the drug and directly affecting the therapeutic effect
In addition, conventional oral dosage forms, such as tablets, capsules, etc., will produce relatively large dust pollution due to the granulation process in the preparation process, which will cause harm to the health of the staff to a certain extent, and will also cause harm to the human body. some pollution to the environment
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0037] The preparation method of Hugan dripping pills of the present invention will be further described with several groups of specific examples.

[0038] Group 1: Tests with a single matrix

[0039] 1. Raw materials: pig gall paste, schisandra extract, liver protection extract;

[0040] 2. Substrate: polyethylene glycol (1000~20000) , polyoxyl 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl starch, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac, etc. pharmaceutical carrier;

[0041] 3. Proportion: take g or kg as the unit, drug extract: matrix = 1:1~1:9;

[0042] 4. Then prepare according to the process of [Preparation Method] 4-7, that is, Hugan dripping pills of various specifications can be prepared.

[0043] [test results]

[0044] Experiment 1: In order to observe the difference in quality of the Hugan dripping pills prepared when the ratio of drug extracts to different substrates was 1:1, the drug extracts were mixe...

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PUM

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Abstract

A Chinese medicine in the form of dripping pill for preventing and treating chronic hepatitis, metastatic hepatitis and early hepatocirrhosis is prepared from pig gall, schisandra fruit, liver-protecting extract and medicinal auxiliary. Its preparing process is also disclosed.

Description

technical field [0001] The present invention relates to a kind of medicinal composition that has the effects of soothing the liver and regulating qi, invigorating the spleen and eliminating food, and lowering transaminase, and is used for the treatment of chronic hepatitis, persistent hepatitis and early liver cirrhosis, especially pig gall paste powder and schisandra paste 1. The liver-protecting extract is an oral preparation of a pharmaceutical composition prepared as a raw material together with a pharmaceutically acceptable carrier as a matrix. Background technique [0002] According to the national drug standard WS 3 -Hugan Tablet prepared according to the formula and extraction process given in B-1745-94, is a kind of liver and Qi, invigorating the spleen and eliminating food, and reducing transaminase. It is used for chronic hepatitis, persistent hepatitis and early stage Tablet preparations for the treatment of liver cirrhosis and other diseases have been clinicall...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/57A61K36/28A61K36/233A61K36/19A61K36/315A61K35/413A61P1/16A61P31/14
Inventor 曲韵智
Owner 北京伟力康源医药科技开发有限公司