Method for quick screening angiotemsin invertase inhibitor combined using high effieient liquid chromatograph and mass spectrum

A high-performance liquid chromatography and angiotensin technology, applied in the field of analytical chemistry, can solve problems such as long time, and achieve simple operation, accurate and reliable results
CN100434917CInactive Publication Date: 2008-11-19HUNAN NORMAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HUNAN NORMAL UNIVERSITY
Publication Date
2008-11-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

A method of using high efficiency chromatograph and mass spectrum unitedly to quickly screen inhibitor of angiotonin converzyme uses hippuric acid bialkyd as substrate and uses purified rabbit lung angiotonin converzyme as source of angiotonin converzyme for carrying out quick analysis on vitality of angiotonin converzyme in human blood plasma.
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Description

technical field

[0001] The present invention relates to the field of analytical chemistry, in particular to an angiotensin-converting enzyme inhibitor capable of analyzing natural product extracts, monomers and marketed angiotensin-converting enzyme inhibitors in vitro, and human plasma angiotensin High performance liquid chromatography and mass spectrometry analysis method of invertase activity. Background technique

[0002] In recent years, angiotensin inhibitors have become one of the drugs of choice for the treatment of hypertension. Many marketed angiotensin inhibitors, such as belazapril, captopril, enalazapril, etc., have good curative effects on hypertensive diseases. However, some of these angiotensin inhibitors can also cause side effects such as coughing, taste disturbance, blotchy skin, and more. In order to find better and safer angiotensin inhibitors, researchers began to turn to natural products, which aroused great interest from colleagues. Existing method...

Claims

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