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Method for improving resolution of ultrasonic image-forming image, and ultrasonic contrast image-forming apparatus

A technology of contrast-enhanced ultrasound and resolution, which is applied in ultrasound/acoustic/infrasonic diagnosis, sonic diagnosis, infrasonic diagnosis, etc. It can solve the problems of the difficulty in qualitative diagnosis of tumors and the inability to display the internal structure and boundaries of tumors with microvascular perfusion characteristics.

Inactive Publication Date: 2009-01-21
BEIJING CANCER HOSPITAL PEKING UNIV CANCER HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, the images obtained by using the second-generation ultrasound contrast agent to perform ultrasound on tumors mainly show the enhancement and exit characteristics of microbubbles in the microvascular bed of tumor tissue, and cannot show the internal structure of the tumor well while showing the characteristics of microvascular perfusion. and boundary, when the internal blood supply of the tumor has individual differences or abnormalities, the qualitative diagnosis of the tissue and tumor will be difficult

Method used

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  • Method for improving resolution of ultrasonic image-forming image, and ultrasonic contrast image-forming apparatus
  • Method for improving resolution of ultrasonic image-forming image, and ultrasonic contrast image-forming apparatus
  • Method for improving resolution of ultrasonic image-forming image, and ultrasonic contrast image-forming apparatus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Example 1: Imaging and diagnostic results of patients with suspected space-occupying in ultrasound examination

[0064] The instrument used is Toshiba Aplio ultrasonic diagnostic instrument. Method 1 (BEUS): This method is routine high-mechanical index scanning imaging before contrast agent administration, that is, before the administration of contrast agent, the main frequency is 4.0MHz to scan the liver mass, and the abdominal scan is selected on the ultrasonic instrument. The default conditions of the investigation (see the manual of the ultrasonic instrument for details), and the parameters with a mechanical index of 1.4 were used for imaging. Method 2 (CEUS): This method is a contrast-enhanced ultrasonography low mechanical index scanning imaging method, that is, the default conditions of contrast-enhanced ultrasonography scanning are selected on the ultrasonic instrument (see the manual of the ultrasonic instrument for details), and the contrast-enhanced ultrasono...

Embodiment 2

[0068] Example 2: Imaging and diagnostic results of a patient with a hepatic mass found on physical ultrasound examination

[0069] The instrument used is Toshiba Aplio ultrasonic diagnostic instrument. The specific operation is the same as the method in Example 1, except that the following adjustments are made: Method 1 (BEUS): the probe frequency is 4.0 MHz, and the mechanical index is 1.4. Method 2 (CEUS): The probe frequency is 4.0MHz and the mechanical index is 0.08. Method 3 (AEUS): 30 seconds after the low mechanical index scanning imaging of contrast-enhanced ultrasound, the probe frequency was 4.0 MHz, and the mechanical index was 1.4 for re-imaging. Method 4: Operate the lesion and take pictures of the surgical specimens.

[0070] The results and analysis of method 1 (BEUS): the spatial resolution of the image is high, but the contrast resolution is low, the rod-shaped tumor in the left lobe, the echo is uneven, the display of the anterior wall is disturbed by near...

Embodiment 3

[0074] Example 3: Imaging and diagnostic results of patients with elevated AFP found in hepatitis B in the past twenty years (AFP>400ng / ml)

[0075] The instrument used is the Technos MPX ultrasonic diagnostic instrument of Esaote Company. The specific operation is the same as the method in Example 1, except that the following adjustments are made: Method 1 (BEUS): the probe frequency is 3.5 MHz, and the mechanical index is 0.4. Method 2 (CEUS): The probe frequency is 2.5MHz and the mechanical index is 0.053. Method 3 (AEUS): 1 minute after the low mechanical index scan of contrast-enhanced ultrasound, the probe frequency was 3.5 MHz and the mechanical index was 0.4 for re-imaging.

[0076] The results and analysis of method 1 (BEUS): the spatial resolution of the image is high, but the contrast resolution is low, the echo in the right lobe of the liver is uneven, and no obvious tumor is seen (see Figure 3A ).

[0077] The results and analysis of method 2 (CEUS): the image...

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Abstract

A method for improving the definition of ultrasonic image features that after a low mechanical index is used for scanning, the low mechanical index is regulated to high mechanical index. An ultrasonic imaging method features that after a low mechanical index is used to scan for finishing the ultrasonic image, the contrast medium micro-bubble residual in the tissue and a high mechanical index are used for instantaneous ultrasonic imaging to obtain high-definition image of tissue. An ultrasonic imaging method for diagnosing tumor with high correctness is also disclosed.

Description

technical field [0001] The invention relates to a method for improving the resolution of contrast-enhanced ultrasound images; at the same time, the invention also relates to a contrast-enhanced ultrasound imaging method and a contrast-enhanced ultrasound diagnosis method; in addition, the invention also relates to a contrast-enhanced ultrasound imager. Background technique [0002] Contrast-enhanced ultrasound (CEUS) imaging is a very important technique that can be used to study tissues with vasculature, such as tumor tissues in solid organs such as the liver. Contrast-enhanced ultrasound is a technique that uses contrast agents to enhance backscatter echoes and significantly improve ultrasound sensitivity and specificity. According to the type of gas encapsulated in the microbubbles, contrast agents can be divided into two generations. The first-generation contrast agent microbubbles contain air, and the second-generation contrast agent microbubbles contain inert gas. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B8/00
Inventor 陈敏华杨薇
Owner BEIJING CANCER HOSPITAL PEKING UNIV CANCER HOSPITAL
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