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Disintegrator carboxymethylstarch sodium preparation method

A technology of carboxymethyl starch sodium and disintegrant, which is applied in the field of preparation of pharmaceutical excipients to achieve the effect of good swelling performance and good fluidity performance

Active Publication Date: 2009-06-10
ANHUI SUNHERE PHARMA EXCIPIENTS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The present invention improves the existing preparation method aiming at the defects of the existing sodium starch glycolate used as a disintegrant, aiming to provide a sodium starch glycolate with better performance as a disintegrating agent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] Now taking potato starch as an example, non-limiting examples are described as follows:

[0016] 1. Cross-linking: Put 700Kg of 85% ethanol and 450Kg of potato starch into the reaction tank. When the temperature rises to 40°C, add 55% of lye. When the pH value of the solution in the tank is adjusted to 9, put in 30Kg of cross-linking agent to keep the reaction The temperature is 40°C, and the cross-linking reaction takes 200 minutes.

[0017] 2. Etherification: After the cross-linking reaction is finished, pump 300Kg of 85% ethanol into the reaction tank, drop in 80Kg of chloroacetic acid and 20Kg of propylene oxide, and start stirring. Add 55% lye, adjust the pH value of the solution in the tank to 11, raise the temperature to 60°C, keep the reaction temperature at 60°C, and carry out the etherification reaction for 300 minutes.

[0018] 3. Refining: After the etherification reaction is completed, the material is discharged and centrifuged.

[0019] Neutralization: P...

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PUM

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Abstract

The invention discloses a preparing method of disintegration agent sodium carboxymethylstarch, which is characterized by the following: adapting starch as raw material through crosslinking, etherification (1.2-4.5 percent oxirane or epoxypropane of starch weight), refining and drying procedure, possessing 25 times absorbent buckling rate and excellent fluidity; overcoming the adhesive effect of present product; accelerating agent disintegration and releasing; saving the additional quantity by half to two thirds.

Description

1. Technical field [0001] The invention relates to a preparation method of a pharmaceutical auxiliary material, in particular to a preparation method of a disintegrating agent carboxymethyl starch sodium. 2. Background technology [0002] Carboxymethyl starch sodium is used as a disintegrant. The traditional preparation process is through cross-linking, etherification, refining, drying, crushing and packaging. The specific process is: [0003] 1. Cross-linking: Put 700Kg of 82% ethanol and 450Kg of cornstarch into the reaction tank. When the temperature rises to 40°C, add 55% lye. When the pH of the solution in the tank is adjusted to 9, put in 30Kg of cross-linking agent. Cross-linking reaction 150 minutes. [0004] 2. Etherification: After the cross-linking reaction is finished, pump 250Kg of 82% ethanol into the reaction tank, put 80Kg of chloroacetic acid into it, and start stirring. Add 55% lye, adjust the pH value of the solution in the tank to 11, raise the temperat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B31/08A61K47/36
Inventor 尹正龙余伟朱岩
Owner ANHUI SUNHERE PHARMA EXCIPIENTS