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Belladonna extract preparing process

A technology of belladonna extract and belladonna herb, which is applied in the field of medicine, can solve the problems of incomplete extraction of alkaloids, and achieve the effect of improving drug efficacy

Active Publication Date: 2009-06-17
XIUZHENG PHARMA GROUP HOIDING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is the shortcoming that the alkaloid contained in belladonna is extracted incompletely in said method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Get 1000 grams of belladonna coarse powder, according to the percolation method (two appendix 10 of Chinese Pharmacopoeia version in 2000) under the extract item, soak 20 hours with 80% ethanol, slowly percolate with the speed of 3 milliliters per hour, collect The filtrate was 6000 ml, the ethanol was recovered under reduced pressure, and the liquid extract was stored in a separate container; the dregs were decocted twice, each time adding 6 times of water, and the decoction time was 1 hour each, filtered, and the filtrates were combined and concentrated to a relative density of 1— 1.4, continue to concentrate under reduced pressure to a thick paste after merging and mixing with the liquid extract extracted with ethanol, and measure the atropine content until the atropine content reaches more than 0.5% (g / g).

Embodiment 2

[0036] Get 1000 grams of belladonna coarse powder, according to the percolation method (two appendix 10 of Chinese Pharmacopoeia version in 2000) under the extract item, soak 24 hours with 85% ethanol, slowly percolate with the speed of 5 milliliters per hour, collect The filtrate was 6000 ml, the ethanol was recovered under reduced pressure, and the liquid extract was stored in a separate container; the dregs were decocted twice, each time adding 6 times of water, and the decoction time was 2 hours each, filtered, and the filtrates were combined and concentrated to a relative density of 1- 1.4, continue to concentrate under reduced pressure to a thick paste after merging and mixing with the liquid extract extracted with ethanol, and measure the atropine content until the atropine content reaches more than 0.5% (g / g).

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PUM

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Abstract

The present invention is belladonna extract preparing process and belongs to the field of medicine technology. The belladonna extract preparing process includes the following steps: crushing belladonna herb; soaking in and percolating with 50-90 % concentration alcohol solution to obtain filtrate and decompression recovering alcohol to prepare extractum; water decocting the belladonna residue after alcohol extraction for 1-4 times, filtering, merging filtrate and concentrating to relative density of 1-1.4; merging the alcohol extracted extractum and the concentrated liquid; and further concentration to obtain the belladonna extract. Compared with available technology, the belladonna extract has 10-15 % raised atropine content and thus raised medicinal effect.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a preparation method of belladonna extract, and the international patent classification number is: C07G 5 / 00. Background technique [0002] At present, the processed extract of belladonna is an anticholinergic drug, which can relieve smooth muscle spasm and inhibit gland secretion, and is widely used in the treatment of gastric and duodenal ulcers, gastrointestinal tract, kidney, and biliary colic drugs; The compatibility of belladonna extract with vitamin U and aluminum hydroxide is a medicine with better effect in treating stomach pain, bloating and gastric acid. The extraction method of belladonna extract is: take belladonna coarse powder, flow the extract and percolation method under the item of extract, use 85% ethanol as solvent, soak for 48 hours, and distill at 1-3 ml per minute Slowly infiltrate at a high speed, collect the initial eluate and store it in another device...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/81A61K9/06A61P1/04C07G5/00
Inventor 高陆
Owner XIUZHENG PHARMA GROUP HOIDING
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