Sinusoidal tensile cell loader

Abstract

A sinusoidal tension cell loading device relates to a cell mechanical loading device in medical experiment instruments. The invention mainly includes a frame, a gear reduction speed regulating motor, a digital display speed governor, a crank slider mechanism and a stretching movement mechanism. The slider crank mechanism is mainly composed of an adjusting screw rod, a crank arm slider, a crank and a pull rod; the stretching motion mechanism is mainly composed of a sliding bracket, a fixed bracket, a guide rod, a front guide rod block and a rear guide rod block. Since the present invention has the characteristics of simple structure, easy operation, convenient maintenance, low cost, stable operation, high cost performance, uniform stress on cells, adjustable stretching amplitude and frequency, etc., the stretching distance can be easily adjusted within the range of 0-25mm, It can meet the mechanical stimulus response research of tensile loading of various adherent growth cells, so the present invention can be widely used as a cell mechanical loading device in medical experimental instruments, and is especially suitable for wide application in research institutions lacking funds and professional operators .

Description

technical field [0001] The invention belongs to the technical field of biomechanical engineering, in particular to a sinusoidal loading device for cell mechanics in medical experiment instruments. technical background [0002] With the development of tissue engineering and biomedical engineering, cell mechanics and tissue engineering have become frontier subjects in the development of modern biology. In order to study the effects of various physical and biochemical factors on human tissues, it is necessary to solve the problem of how to mechanically load cells. In the existing cell loading device, such as the patent of "Four-Point Bending Cell Mechanics Loading Apparatus" with publication number CN1425905A, it is disclosed that the stepper motor executes the commands of the CPU, thereby driving the punching head to run various speeds, displacements, stamping The head deforms the beam between the four support points of left and right symmetry, so that the surface area of ​​t...

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Problems solved by technology

The advantage of this loading instrument is that the control operation is completed by the CPU, and the cells are stretched or compressed in different forms through a stepping motor. However, the main problems of this loading instrument are: 1. The beam is between the four supporting points The deformation of the cell is uneven, which will inevitably lead to uneven deformation of the adherent growth cells on the culture plate

2. The deformation between the four support points is determined by the displacement of the stamping head and converted through the middle of the beam, which makes the cell deformation unintuitive and will cause errors

3. The loading instrument cannot achieve microscopic observation of cells under tension or compression

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