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Use of red sage root extract in preparing antithrombotic pharmaceutical composition

An antithrombotic drug and polysaccharide extraction technology, which can be used in drug combinations, blood diseases, pharmaceutical formulations, etc.

Inactive Publication Date: 2009-08-26
INST OF PHARMACY SHANDONG PROV ACAD OF MEDICAL SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no reports on the antithrombotic effect of polysaccharides from traditional Chinese medicines at home and abroad, and there are no reports on the studies on polysaccharides from salvia miltiorrhiza

Method used

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  • Use of red sage root extract in preparing antithrombotic pharmaceutical composition
  • Use of red sage root extract in preparing antithrombotic pharmaceutical composition
  • Use of red sage root extract in preparing antithrombotic pharmaceutical composition

Examples

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Effect test

Embodiment 1

[0080] Take 0.9 kg of Danshen rhizome, add 8 kg of water, boil for 1.5 hours, filter, and set aside the filtrate, add 8 kg of water to the dregs, boil and extract for 1 hour, filter, combine the two filtrates, concentrate the combined filtrate and spray dry to obtain the polysaccharide 10% Danshen polysaccharide extract. Add 4 times the extract to dissolve, add ethanol until the ethanol content is 80%, let it stand still, filter and dry, and obtain the salvia miltiorrhiza polysaccharide extract with 50% salvia miltiorrhiza polysaccharide and has antithrombotic activity.

[0081] The pure Danshen polysaccharide extract is made into tablets or capsules of 0.3 g per tablet according to conventional methods for clinical oral treatment of thrombosis. When using this product, take tablets or capsules three times a day, 0.3-0.6g each time.

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PUM

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Abstract

The invention provides a radix salvia miltiorrhiza extract with antithrombotic activity, which is prepared from radix salvia miltiorrhiza root or rhizome as raw material through disintegrating, solvent extraction and refining, the radix salvia miltiorrhiza extract has a content of radix salvia miltiorrhiza polysaccharides greater than 80%.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, and relates to the application of plant salvia miltiorrhiza extract in preparing new medicines. Background technique [0002] The following definitions apply throughout the specification and claims: [0003] Danshen polysaccharide: refers to a polysaccharide compound extracted from the effective part of Danshen. After hydrolysis, the polysaccharide compound is analyzed on a silica gel plate by thin layer. It is known that Danshen polysaccharide is composed of mannose, galactose, glucose, xylose and some unknown Polysaccharides composed of monosaccharides. [0004] Thrombosis is one of the diseases that seriously endanger human health, and it is also a research focus of medical scientists from all over the world. Searching for new active ingredients from natural products, and then developing new drugs is also an important way to overcome clinical chronic diseases. The present inventio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61P7/02A61K125/00
Inventor 邢来田仲英王福文王菊王芃刘鲁张秀芹杨尚军胡志力刘爱芹朱燕李杰许双庆
Owner INST OF PHARMACY SHANDONG PROV ACAD OF MEDICAL SCI