Method for extracting bitter buckwheat flavone in high purity

The tartary buckwheat flavonoids and the extraction method technology are applied in chemical instruments and methods, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve the problems of complex technological process, high production cost, and high ointment yield, and reach the level of refinement. High, low production cost, the effect of reducing the process

Inactive Publication Date: 2009-12-09
SHANXI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention provides a new extraction method of tartary buckwheat flavonoids—a high-purity tartary buckwheat flavonoids in order to solve the shortcomings of the existing tartary buckwheat flavonoids extraction method, such as high cream yield, low purity, complex process flow, and high production cost. extraction method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] 1. Extraction

[0014] Get the original medicinal material of tartary buckwheat (dried seeds 100g). It can be dried or dried before extraction. Wherein tartary buckwheat refers to the dicotyledonous Polygonaceae buckwheat plant. At a temperature of 85°C-100°C, reflux extraction with 1000mL of 60% (or 30% or 40% or 45% or 50% or 55% or 60% or 65% or 70% or 80%) ethanol water for 3 times (1000mLX3), 2hr each time, combine the extracts, filter, and concentrate the filtrate under reduced pressure (60°C, 0.08-0.1MPa) to a total volume of about 500mL, stand at room temperature for 2-4hr, use a high-speed centrifuge or an ordinary centrifuge , put the sample at 15°C~30°C (15°C, 20°C, 25°C, 30°C), centrifuge at 5000r·min -1 , centrifuge the concentrated solution for 15 minutes, discard the supernatant, evaporate the precipitate to dryness in a water bath, and dry it in an oven at 50°C-75°C for 2-72hrs to obtain a yellow-brown to yellow powder, which is high-purity tartary bu...

Embodiment 2

[0020] 1. Extraction

[0021] Get the original medicinal material of tartary buckwheat (dried seeds 100g). It can be dried or dried before extraction. Wherein tartary buckwheat refers to the dicotyledonous Polygonaceae buckwheat plant. At a temperature of 85°C-100°C, reflux extraction with 1000mL of 50% (or 30% or 40% or 45% or 55% or 60% or 65% or 70% or 80%) methanol water for 3 times (1000mLX3) , 2hr each time, combine the extracts, filter, and concentrate the filtrate under reduced pressure (60°C, 0.08-0.1MPa) to a total volume of about 600mL. At 15°C ~ 30°C (15°C, 20°C, 25°C, 30°C), the centrifugal speed is 8000r·min -1 , centrifuge the concentrated solution for 30 minutes, discard the supernatant, evaporate the precipitate to dryness in a water bath, and dry it in an oven at 50°C-75°C for 2-72hrs to obtain a yellow-brown to yellow powder, which is high-purity tartary buckwheat. Extract, the total amount is 2.52g. The paste yield was 2.52%.

[0022] 2. Determination...

Embodiment 3

[0027] 1. Extraction

[0028] Get the original medicinal material of tartary buckwheat (dried seeds 100g). It can be dried or dried before extraction. Wherein tartary buckwheat refers to the dicotyledonous Polygonaceae buckwheat plant. At a temperature of 85°C-100°C, reflux extraction with 1000mL of 70% (or 30% or 40% or 45% or 50% or 55% or 60% or 65% or 80%) acetone water for 3 times (1000mLX3) , 2hrs each time, combine the extracts, filter, and concentrate the filtrate under reduced pressure (60°C, 0.08-0.1MPa) to a total volume of about 400mL, let it stand at room temperature for 2-4hrs, and use a high-speed centrifuge or an ordinary centrifuge to separate the sample At 15°C ~ 30°C (15°C, 20°C, 25°C, 30°C), the centrifugal speed is 13000r·min -1 , centrifuge the concentrated solution for 65 minutes, discard the supernatant, evaporate the precipitate to dryness in a water bath, and dry it in an oven at 50°C-75°C for 2-72hrs to obtain a yellow-brown to yellow powder, whic...

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Abstract

The invention relates to an extraction method of tartary buckwheat flavonoids, in particular to an extraction method of high-purity tartary buckwheat flavonoids. The invention solves the shortcomings of the existing tartary buckwheat flavonoid extraction method, such as high cream yield, low purity, complicated technical process and high production cost. The extraction method comprises reflux extraction and concentration of tartary buckwheat seeds to obtain a concentrated solution and separation and purification of the concentrated solution; 30%-80% ethanol or methanol or propanol or ethyl acetate solution is used for reflux extraction, and the reflux extract is concentrated until bitter The ratio of the weight of the buckwheat seeds to the volume of the extract is 1:4-1:6; the concentrated solution is left to cool, and is centrifuged in a centrifuge at a temperature of 15°C-30°C, the supernatant is discarded, and the precipitated part is dried , to obtain a high-purity extract. The extraction method has fewer procedures, simple equipment, low production cost and enhanced product stability, and is especially suitable for industrialized production. The resulting extract not only has a high degree of refinement, the yield of the paste is below 3%, and the purity of the total flavonoids is above 50%.

Description

technical field [0001] The invention relates to an extraction method of tartary buckwheat flavonoids, in particular to an extraction method of high-purity tartary buckwheat flavonoids. Background technique [0002] Buckwheat is an annual plant of the dicotyledonous Polygonaceae buckwheat. There are two types of cultivated buckwheat: one is common buckwheat, also known as sweet buckwheat (Fagopyrum esculentum), and its grain is triangular; the other is Tartar buckwheat (Fagopymmt ~aricum), commonly known as tartary buckwheat, is smaller than ordinary buckwheat grains, with blunt edges and corners, dark grain color, dull, rough material surface, and hard to fall off. "Compendium of Materia Medica" records: Tartary buckwheat has a bitter, flat, cold taste, is beneficial to energy, maintains spirit, benefits eyes and ears, and has the effect of lowering qi, widening intestines and strengthening stomach. Modern clinical medical observations show that buckwheat has the effects of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/70A61P3/06A61P3/10A61P9/10A61P37/04A61P43/00C07H1/08C07D311/30A61K131/00
Inventor 李青山周瑞雪韩玲革刘恩荔梁泰刚
Owner SHANXI MEDICAL UNIV
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