Lidocaine hydrochloride partial film forming gel composition and uses thereof

A technology of lidocaine hydrochloride and gel composition, which is applied in the field of lidocaine hydrochloride topical film-forming gel composition, can solve the problems of short retention time of medicament and affected area, low therapeutic effect, etc. Good compatibility and good flexibility

Inactive Publication Date: 2009-12-23
SHANGHAI INST OF PHARMA IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the technology of the above-mentioned existing film-forming gel composition is used to prepare lidocaine hydrochloride local film-forming gel, the retention time of the medicament and the affected part will be shorter, and the therapeutic effect will be lower.

Method used

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  • Lidocaine hydrochloride partial film forming gel composition and uses thereof
  • Lidocaine hydrochloride partial film forming gel composition and uses thereof
  • Lidocaine hydrochloride partial film forming gel composition and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～14

[0038] Embodiment 1~14 and comparative example 1'

[0039] The lidocaine hydrochloride (do not add lidocaine hydrochloride in the comparative example) and the esterifying agent of the consumption in embodiment 1~14 and comparative example 1′ in table 1 are stirred and dissolved in the solvent of soluble amount respectively, Slowly add hydroxypropyl cellulose under stirring to completely dissolve / swell, then continue to stir to form a uniform gel; Uniformly; Supplement the solvent of remaining amount, make reach recipe quantity, stir evenly, degas, respectively make lidocaine hydrochloride and the local film-forming gel composition of contrast each 100 grams.

[0040] Table 1

[0041]

[0042] The experimental results show that the lidocaine hydrochloride topical film-forming gel composition is translucent yellow-brown in appearance, and can form a layer of smooth, tough, wear-resistant and durable hydrophobic adhesive film on the surface of the skin / mucosa.

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PUM

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Abstract

The invention discloses a local film-forming gel composition of lidocaine hydrochloride, which comprises the following components in percentage by weight: 0.5-7% of hydroxyalkyl cellulose, 1-10% of esterifying agent, and 0.5-7% of crosslinking agent 5%, solvent 75-90% and lidocaine hydrochloride 0.1-5%; among them, the cross-linking agent is saturated fatty polyol or alkyd, and its general chemical formula is CnH2n+2-m-l(OH)m(COOH) l, n, m, and l are integers, n≥m≥2, l≥0, m+l is 4-8, and n+l is 4-8. The lidocaine hydrochloride film-forming gel composition of the present invention is used for local analgesia of tissues such as mucous membrane / skin, can form one deck smooth, tough, wear-resisting, hydrophobic protective film when being coated on skin or mucous membrane surface, and existing Compared with various topical dosage forms of lidocaine hydrochloride, the film formed by the gel composition is not easy to break, dissolve and / or erode, and the film can be effectively retained on the surface of the oral mucosa for more than 5 hours, and effective on the skin surface. Leaves on for 8+ hours.

Description

technical field [0001] The invention relates to a local film-forming gel composition of lidocaine hydrochloride and its application in alleviating local body tissue pain. Background technique [0002] The pain caused by cuts, abrasions, incisions, scalds, sprains, strains, contusions and oral ulcers on local tissues of the human body is a common disease that people often encounter in their daily lives. Clinically, local analgesic drugs are usually used for analgesic treatment, such as local anesthetics such as lidocaine and benzocaine. The topical pharmaceutical preparations used to alleviate these diseases are usually glue, gel, paste, etc. When these preparations are used for local treatment on the skin or mucosal tissue, due to the normal activities of the treatment site and surrounding tissues, such as friction , The secretion and washing of sweat and saliva will dissolve and / or erode these agents, displace, fall off, and even disappear. The contact time of these topic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K31/167A61K47/12A61K47/10A61K47/38A61P25/04
Inventor 马晋隆陈志明史家骏
Owner SHANGHAI INST OF PHARMA IND CO LTD
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