Lidocaine hydrochloride partial film forming gel composition and uses thereof

Abstract

The invention discloses a local film-forming gel composition of lidocaine hydrochloride, which comprises the following components in percentage by weight: 0.5-7% of hydroxyalkyl cellulose, 1-10% of esterifying agent, and 0.5-7% of crosslinking agent 5%, solvent 75-90% and lidocaine hydrochloride 0.1-5%; among them, the cross-linking agent is saturated fatty polyol or alkyd, and its general chemical formula is CnH2n+2-m-l(OH)m(COOH) l, n, m, and l are integers, n≥m≥2, l≥0, m+l is 4-8, and n+l is 4-8. The lidocaine hydrochloride film-forming gel composition of the present invention is used for local analgesia of tissues such as mucous membrane / skin, can form one deck smooth, tough, wear-resisting, hydrophobic protective film when being coated on skin or mucous membrane surface, and existing Compared with various topical dosage forms of lidocaine hydrochloride, the film formed by the gel composition is not easy to break, dissolve and / or erode, and the film can be effectively retained on the surface of the oral mucosa for more than 5 hours, and effective on the skin surface. Leaves on for 8+ hours.

Description

technical field [0001] The invention relates to a local film-forming gel composition of lidocaine hydrochloride and its application in alleviating local body tissue pain. Background technique [0002] The pain caused by cuts, abrasions, incisions, scalds, sprains, strains, contusions and oral ulcers on local tissues of the human body is a common disease that people often encounter in their daily lives. Clinically, local analgesic drugs are usually used for analgesic treatment, such as local anesthetics such as lidocaine and benzocaine. The topical pharmaceutical preparations used to alleviate these diseases are usually glue, gel, paste, etc. When these preparations are used for local treatment on the skin or mucosal tissue, due to the normal activities of the treatment site and surrounding tissues, such as friction , The secretion and washing of sweat and saliva will dissolve and / or erode these agents, displace, fall off, and even disappear. The contact time of these topic...

AI Technical Summary

Problems solved by technology

If the technology of the above-mentioned existing film-forming gel composition is used to prepare lidocaine hydrochloride local film-forming gel, the retention time of the medicament and the affected part will be shorter, and the therapeutic effect will be lower.

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