Medicinal composition for injections in articular cavity

Abstract

The present invention provides a pharmaceutical composition used for intra-articular injection, the main ingredients of which are sodium hyaluronate and chondroitin sulfate, wherein, the molecular weight of the sodium hyaluronate is 1.2 million to 5 million Daltons and the concentration is 0.5 percent to 2.0 percent, and the molecular weight of the chondroitin sulfate is 2000 to 15000 Daltons andthe concentration is 1 percent to 5 percent. The present invention has the advantages of good viscoelasticity and good buffer capacity of the sodium hyaluronate with relatively high molecular weight,as well as the advantages of rapid absorption and rapid repair of the chondroitin sulfate with relatively low molecular weight, thus the invention can be used for treating the arthritis by intra-articular injection.

Description

Technical field: [0001] The invention belongs to the technical field of medicine and provides a pharmaceutical composition for intra-articular injection. Background technique: [0002] Osteoarthritis is one of the common joint diseases clinically, which is more common in the elderly. With the prolongation of the average human life expectancy and the continuous aggravation of the aging society, the incidence of osteoarthritis in the elderly is also increasing, which seriously reduces the quality of life of the elderly. Therefore, the treatment of arthritis has become a major problem to be solved urgently. [0003] Osteoarthritis caused by various reasons starts from the degeneration of articular cartilage, followed by the changes of bone and synovium. The degeneration of cartilage includes the changes of chondrocytes and matrix. The main clinical manifestations are cartilage destruction, loss, and weakened elasticity; the lubrication of joint synovial fluid and the biologic...

AI Technical Summary

Problems solved by technology

[0004] At present, there are also many methods for the drug treatment of arthritis, such as: controlling inflammation by giving glucocorticoids, but two obvious disadvantages of this method are: 1) Although it can quickly cover up the pain symptoms of arthritis and relieve inflammation, it cannot Fundamentally improve the lesions of cartilage and synovial fluid, but patients often increase their activities because of the relief of pain, aggravating the degree of lesions of cartilage and synovial fluid, and further aggravating arthritis; 2) Glucocorticoids have obvious adverse reactions, greatly limit its application

However, although the application of sodium hyaluronate alone can directly repair the damaged cartilage and treat osteoarthritis fundamentally, the repair speed is slow and the course of treatment is longer.

Images