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Sustained release composition

A composition and sustained-release technology, applied in drug combination, drug delivery, food science, etc., can solve problems such as treatment and response time lag

Inactive Publication Date: 2007-07-18
SMART DRUG SYST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] Furthermore, in prior art there is a significant time lag between treatment and response

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0197] Study on the release of deslorelin acetate from solid sustained-release implants in pigs

[0198] Study Number: DSL-P-03-001

[0199] Research site: Pig Research and Training Center (Pig Research and TrainingCentre, PRTC)

[0200] Victorian Institute of Animal Science

[0201] Department of Primary Industries

[0202] 600 Sneydes Road

[0203] Werribee Victoria Australia 3030

[0204] Implants:

[0205] Three different implant formulations were evaluated.

[0206] Dosage Form No. 1 consists of deslorelin acetate and DOC and mannitol as additives.

[0207]Formulation No. 2 consists of deslorelin acetate and NaCl and dextran as additives.

[0208] Dosage form number 3 consists of deslorelin acetate without additives.

[0209] Implant size and duration of treatment:

[0210] Groups of pigs were treated with implants of different lengths and for different durations.

[0211] Pigs were treated with implants 1 cm, 0.5 cm or 0.25 cm in length. All implants have a di...

Embodiment 2

[0280] Study on the release of deslorelin acetate from porcine sustained-release implants

[0281] Study Number: DSL-P-04-001

[0282] Research site: Pig Research and Training Center (Pig Research and TrainingCentre, PRTC)

[0283] Victorian Institute of Animal Science

[0284] Department of Primary Industries

[0285] 600 Sneydes Road

[0286] Werribee Victoria Australia 3030

[0287] Implants:

[0288] Three different implants were evaluated.

[0289] Implant No. 3 consisted of 36% deslorelin acetate without additives and had an outer diameter of 1.5 mm.

[0290] Implant No. 4 consisted of 54% deslorelin acetate without additives and had an inner diameter of 1.5 mm.

[0291] Implant No. 5 consisted of 36% deslorelin acetate without additives and had an outer diameter of 2.0 mm.

[0292] Implant size and duration of treatment:

[0293] Groups of pigs were treated with implants of varying lengths, but all treatments totaled 1 cm total implants. Pigs were treated for ...

Embodiment 3

[0324] Study on the release of deslorelin acetate from porcine sustained-release implants

[0325] Study Number: DSL-P-04-002

[0326] Research site: Pig Research and Training Center (Pig Research and TrainingCentre, PRTC)

[0327] Victorian Institute of Animal Science

[0328] Department of Primary Industries

[0329] 600 Sneydes Road

[0330] Werribee Victoria Australia 3030

[0331] Implants:

[0332] The various implants were evaluated as follows.

[0333] Implant type 2 consisted of 54% deslorelin acetate and had an inner diameter of 1.4 mm and an outer diameter of 1.6 mm.

[0334] Implant size and duration of treatment:

[0335] Three groups of pigs were treated as follows.

[0336] · Group 1 - 10 boars - untreated (control)

[0337] · Group 2 - 5 boars - 9.6 mg deslorelin - treatment for 2 weeks

[0338] · Group 3 - 5 boars - 9.6 mg deslorelin - treatment for 4 weeks

[0339] Pigs were treated with 1 cm (ie 4 x 0.25 cm) implants cut to 0.25 cm length.

[034...

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Abstract

A sustained release apparatus including at least one sustained release mini-implant or pellet; the or each mini-implant or pellet including: a sustained release support material; and a pharmaceutical composition including a Luteinising Hormone Releasing Hormone (HLRH) agonist and / or antagonist component the size and / or number and / or payload of mini-implant(s) or pellet(s) providing, release of LHRH agonist and / or antagonist at, or above, a desired threshold level for treatment of a selected indication, the apparatus providing approximately zero order release of the LHRH agonist and / or antagonist.

Description

field of invention [0001] The present invention relates to sustained release devices, especially in the form of implants or pellets. More specifically, the present invention relates to sustained release devices for use in the treatment of various indications associated with hormone production in animals, including humans. Background of the invention [0002] In the prior art, many drug delivery systems are known. [0003] For example, a controlled-release pharmaceutical preparation that uses a hydrophobic polymer material that does not degrade after administration to a living body as a carrier. There are two methods for controlling drug release from such preparations: one, using additives such as albumin (Japanese Patent Laid-Open (Tokkohei) No. 61959 / 1995); (Japanese Patent Laid-Open (Tokkohei) No. 187994 / 1995). [0004] However, drug delivery systems known in the prior art often exhibit drug loading when disease indications require reaching high plasma level thresholds ...

Claims

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Application Information

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IPC IPC(8): A61K38/09A61K38/00A61P5/28A61P15/16A61P15/18A61P15/08A61P35/00A23L13/00A61K9/00A61K9/20A61K38/24
CPCA61K9/2013A61K9/0024A61K38/24A61K9/2018A61K9/2009A61P3/00A61P5/26A61P5/28A61P13/08A61P15/00A61P15/08A61P15/16A61P15/18A61P35/00A61P43/00
Inventor M·布兰登S·马蒂诺德
Owner SMART DRUG SYST
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