Optical fibre embedded low-voltage actuated capillary tube electrophoresis chip

A technology of capillary electrophoresis and low voltage, which is applied in the research field of micro-total analysis system in analytical chemistry, which can solve the problems that have not yet been commercialized, and achieve the effects of improving detection sensitivity, simplifying detection optical path, and reducing volume

Inactive Publication Date: 2007-08-08
DALIAN UNIV OF TECH
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  • Abstract
  • Description
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Problems solved by technology

[0005] At present, there are few domestic and foreign reports on capillary electrophoresis chips that replace high separation voltages with low voltag

Method used

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  • Optical fibre embedded low-voltage actuated capillary tube electrophoresis chip
  • Optical fibre embedded low-voltage actuated capillary tube electrophoresis chip
  • Optical fibre embedded low-voltage actuated capillary tube electrophoresis chip

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Embodiment Construction

[0016] The specific implementation of the present invention will be described in detail below in conjunction with the technical scheme and accompanying drawings. The analysis process of the capillary electrophoresis chip mainly includes several processes of sample filling, sample injection, separation and detection. Due to the small size of the microchannel and the small volume of the sample, the electroosmotic driving method is the most widely used at present, and the switching operation of the microfluidic flow is completed by applying a high DC voltage.

[0017] The process of sample filling, sample injection and separation in the present invention is realized by using the "low-voltage drive array electrode capillary electrophoresis chip" that the inventor has applied for a patent. Road 13 and separation channel 17, as shown in Figure 5. When filling the sample, the external voltage is applied between the electrode 18 of the sampling channel and the array electrode 23 shown...

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Abstract

The invention is a fiber embedded low-voltage drive capillary electrophoresis chip, relating to the analysis chemical micro total analysis system research technology field, particularly to the capillary electrophoresis chip production. The fiber embedded low-voltage drive capillary electrophoresis chip comprises the glass substrate and glass film; on the glass substrate embedded detection fiber for signal detection, and the low-voltage drive array electrode capillary electrophoresis chip and detection fiber are integrated into a chip, that is to say, the cruciform ditch on the glass substrate and platinum array electrode of detection fiber and the glass-film are combined together. On the glass substrate, by chemical corrosion, etch a laser importing fiber channel vertical to the separation ditch, and the fiber channel to transmit the excitation fluorescence. It reduces the injection and separation voltage, simplifies the detection optical path, narrows capillary electrophoresis chip detection system volume, improves detection sensitivity, and achieves the detector miniaturization and integration.

Description

technical field [0001] The invention relates to the research technical field of micro-total analysis system in analytical chemistry, in particular to the manufacture of a capillary electrophoresis chip, which realizes the miniaturization and integration of a detector by using a relatively low sample injection and separation voltage and an embedded detection optical fiber. Background technique [0002] The integrated capillary electrophoresis chip is an important branch in the development of micro-device systems. It combines biotechnology, microelectronics technology and MEMS technology to integrate various channels, electrode slots, detection flow cells, etc. into the same substrate. Electrophoresis instrument is a multi-functional micro analysis device with fast, high efficiency, high sensitivity and low sample volume. Since 1991, the international development of integrated capillary electrophoresis chip manufacturing technology and its application in rapid analysis in biol...

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Application Information

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IPC IPC(8): G01N21/01G01N21/64G01N27/453B01D57/02
Inventor 闫卫平吕宏峰李鹤楠
Owner DALIAN UNIV OF TECH
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