Chromatographic exclusion agglutination assay and methods of use thereof

An aggregate, detected technology, used in measurement devices, biological testing, analysis by chemically reacting materials, etc., to solve problems such as lack of sensitivity and false positive results
CN101019023AInactive Publication Date: 2007-08-15BINAX INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BINAX INC
Publication Date
2007-08-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to agglutination assays and in particular to chromatographic exclusion assays and methods of use thereof. The present invention includes a novel strategy for determining the presence of one or more analytes on interest in a test sample by using chromatographic exclusion of aggregates of bound detectable specific binding reagents that are accumulated at a particular and non-random location on the test device. In the absence of analytes of interest in the sample under test, the specific detectable binding reagent aggregates are not formed, and hence not excluded from the chromatographic media creating a distinct and readily differentiating event. The present invention is particularly adaptable as a simple test device for detection of diseases or monitoring of treatments at a doctor's office or in the home.
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Description

field of invention

[0001] The present invention relates generally to the field of agglutination assays, and in particular to chromatographic exclusion assays and methods of use thereof. Background of the invention

[0002] Various air agglutination assays are commercially available. These agglutination assays can be used for a variety of purposes, such as diagnosing disorders or monitoring treatment by analyzing samples for trace analytes of interest. Some agglutination assays are performed entirely in solution, and the presence of visible analyte-induced aggregates in solution is indicative of a positive result. Other agglutination assays are performed using flow-through systems that pass reaction samples through small holes to concentrate analyte-induced aggregates. For other agglutination assays performed on dried porous strips, the presence of analyte-induced aggregates on the strip is a positive result.

[0003] Many available agglutination assays suffer from a lack ...

Claims

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