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Antibiotic silver-carrying modified artificial coral bone and its prepn process

An artificial bone and antibacterial technology, applied in the field of biomedical materials, can solve the problems of body poisoning and death, and achieve the effect of preventing re-infection and accelerating healing

Inactive Publication Date: 2007-08-22
GUANGZHOU MAIBANG BIOLOGICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, scientific research shows that excessive heavy metal elements can lead to poisoning of the body and even death

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Prepare the self-made modified coral artificial bone into 20 cube particles of 5mm×5mm×5mm. After ultrasonic cleaning and drying, the above particles are completely soaked in a 10ml small beaker filled with 0.01M silver nitrate solution. Freeze-dry at low temperature, add 10ml of 0.01M sodium chloride into a beaker after freeze-drying, and freeze-dry at low temperature in vacuum under the condition of avoiding light. The cryogenic freeze-drying temperature is -30°C, -50°C or -70°C. The obtained product was dialyzed with distilled water for 24 hours to obtain a modified coral artificial bone loaded with silver chloride precipitate. The weight percentage of calcium carbonate in the modified coral artificial bone is 30%-70%, which is derived from natural coral, retains its three-dimensional porous structure, has a porosity of 10-90%, and a pore diameter of 100-500um.

Embodiment 2

[0030] Prepare the self-made modified coral artificial bone into 20 cube particles of 5mm×5mm×5mm. After ultrasonic cleaning and drying, the above particles are completely soaked in a 10ml small beaker filled with 0.005M silver nitrate solution. Freeze-dry at low temperature, add 10ml of 0.005M sodium chloride into a beaker after freeze-drying, and freeze-dry under vacuum and low temperature under the condition of avoiding light. The cryogenic freeze-drying temperature is -30°C, -50°C or -70°C. The obtained product was dialyzed with distilled water for 24 hours to obtain a modified coral artificial bone planted with silver chloride. The main components of the modified coral artificial bone are carbon, oxygen, calcium, phosphorus, and silver, wherein the carbon content is ≤40%, the oxygen content is ≤30%, the calcium content is ≤50%, and the phosphorus content is ≤50%. , Silver content ≤ 5%. All the other are with embodiment 1.

Embodiment 3

[0032] Prepare the self-made modified coral artificial bone into 20 cube particles of 5mm×5mm×5mm. After ultrasonic cleaning and drying, the above particles are completely soaked in a 10ml small beaker filled with 0.001M silver nitrate solution. Freeze-dry at low temperature, add 10ml of 0.001M sodium chloride into a beaker after freeze-drying, and freeze-dry under vacuum and low temperature under the condition of avoiding light. The cryogenic freeze-drying temperature is -30°C, -50°C or -70°C. The obtained product was dialyzed with distilled water for 24 hours to obtain a modified coral artificial bone planted with silver chloride.

[0033] The silver-loaded modified coral artificial bone samples obtained in the above-mentioned 3 embodiments carry out the following detection:

[0034] The scanning electron microscope of the Guangzhou Institute of Geochemistry, Chinese Academy of Sciences confirmed that the silver-loaded modified coral artificial bone maintains a good three-d...

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Abstract

The antibiotic silver-carrying modified artificial coral bone consists of modified artificial coral bone with controllable degradation speed as carrier and adsorbed silver ion particle. The modified artificial coral bone consists of calcium carbonate in 30-70 wt% and hydroxyapatite. The preparation process of the antibiotic silver-carrying modified artificial coral bone includes the following steps: 1. preparing modified artificial coral bone; 2. soaking the artificial coral bone in silver nitrate solution, heliophobic vacuum low temperature freeze drying, adding sodium chloride solution to form silver chloride precipitate on the surface of the artificial bone and heliophobic vacuum low temperature freeze drying; and 3. distilled water dialysis to prepare antibiotic silver-carrying modified artificial coral bone.

Description

technical field [0001] The invention relates to an antibacterial silver-loaded modified coral artificial bone and a preparation method thereof, which is an ideal anti-infection artificial bone filling material. Suitable for applications in orthopedic trauma surgery and plastic and reconstructive surgery. Belonging to the field of biomedical materials, Background technique [0002] At present, there are few clinical treatment methods for infected or contaminated bone defects. Usually, debridement and drainage are performed first, and autologous bone grafting is performed again after the infected wound heals. The treatment cycle is long and the effect is poor. There are also some scholars who combine artificial bone with certain antibiotics to treat infectious or polluted bone defects, but after all, due to the limited antibacterial spectrum of antibiotics, bacteria will produce antibodies after about 3 days of application, resulting in protein denaturation, resulting in dru...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/54
Inventor 张余尹庆水
Owner GUANGZHOU MAIBANG BIOLOGICAL SCI TECH
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