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Bacteria resisting medicine of erythrocin nanometer-emulsion and the preparing method

A technology of antibacterial drugs and nanoemulsions, applied in the field of medicine, can solve the problems of drug efficacy, side effects, and price differences, and achieve the effects of simple preparation methods, low toxicity, and high safety

Inactive Publication Date: 2007-09-12
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although many erythromycin derivatives have emerged in recent years to overcome these shortcomings, they differ in varying degrees in terms of efficacy, side effects and prices.

Method used

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  • Bacteria resisting medicine of erythrocin nanometer-emulsion and the preparing method
  • Bacteria resisting medicine of erythrocin nanometer-emulsion and the preparing method
  • Bacteria resisting medicine of erythrocin nanometer-emulsion and the preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1 preparation drug concentration is the erythromycin nanoemulsion of 0.5%

[0042] Erythromycin 0.5g

[0043] Absolute ethanol 5.0g

[0044] Tween-80 15.0g

[0045] Ethyl acetate 2.2g

[0046] Distilled water 78.3g

Embodiment 2

[0047] Embodiment 2 preparation drug concentration is the erythromycin nanoemulsion of 0.5%

[0048] Erythromycin 0.5g

[0049] Absolute ethanol 5.0g

[0050] Tween-80 15.0g

[0051] Ethyl acetate 5.0g

[0052] Distilled water 74.5g

Embodiment 3

[0053] Embodiment 3 preparation drug concentration is the erythromycin nanoemulsion of 1%

[0054] Erythromycin 0.5g

[0055] Absolute ethanol 5.0g

[0056] Tween-80 15.0g

[0057] Ethyl acetate 2.2g

[0058] Distilled water 27.3g

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Abstract

The nanometer antibacterial erythromycin medicine consists of erythromycin in 0.5-1.5 wt% and nanometer emulsion matrix in 98.5-99.5 wt%. It is yellowish transparent liquid, and has medicine granularity of 1-100 nm, low viscosity, high stability, fast absorption, targeted medicine release, high bioavailability, less toxic side effect and other features. The medicine may be attached well onto bacteria and permeated into bacteria to disturb their metabolism and to reach bacteriostasis and bactericidal effect. It is used mainly for treating serious infection caused by penicillin resisting staphylococcus aureus and hemolytic streptococcus as well as chicken's chronic respiratory tract disease, malignant rhinitis, etc. The medicine has simple preparation process, less toxicity and high safety.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new dosage form of an antibacterial drug, in particular to an erythromycin nanoemulsion antibacterial drug and a preparation method thereof. Background technique [0002] Erythromycin is a macrolide antibiotic, mainly used for severe infections caused by drug-resistant Staphylococcus aureus and hemolytic streptococci, such as pneumonia, sepsis, endometritis, mastitis, etc.; Chronic respiratory diseases, mycoplasma pneumonia also have a good effect. It is not only used in human medicine, but also has broad application prospects in veterinary medicine. However, the traditional dosage form of erythromycin is easily destroyed by gastric acid when taken orally, and a considerable amount is also inactivated in the liver, resulting in a large dosage, short half-life in the body, frequent administration, and obvious gastrointestinal reactions. Although many erythromycin derivatives have emerged ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/107A61P31/04
Inventor 欧阳五庆芮亚培
Owner NORTHWEST A & F UNIV
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