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New medical using of vitex and method for preparing medicinal intermediate

A technology of Vitex and medicine, which is applied in the application field of preparing anti-tumor and osteoporosis drugs, and can solve problems such as the effect of Vitex lignans on osteoporosis that have not been found

Inactive Publication Date: 2007-10-24
CHANGSHA SANYOU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] In conclusion, no anti-tumor and anti-osteoporosis effects of vitex lignans have been found so far

Method used

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  • New medical using of vitex and method for preparing medicinal intermediate
  • New medical using of vitex and method for preparing medicinal intermediate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0105] Embodiment 1 (raw material is Fructus Chinensis)

[0106] A. Herbal decoction

[0107](A) 10 kg of Chrysanthemum Vitex is pulverized and added to the container, then 80 liters of 40% ethanol solution is added to the container, and then the mixture of the two is heated to 85° C., kept for 1.5 hours, and the filter residue is taken.

[0108] (B) Add 60 liters of 40% ethanol solution to the residue filtered out in step A (A), and heat the mixture of the two to 85° C., after 1 hour of heat preservation, take the liquid from the filter residue.

[0109] (C) Add 60 liters of 40% ethanol solution to the residue filtered out in step A (B), and heat the mixture of the two to 85° C., keep it warm for 1 hour, and take the liquid from the filter residue.

[0110] B. Liquid Concentration

[0111] The liquids prepared by each of the A steps (A), (B) and (C) were mixed together and then concentrated under reduced pressure until concentrated to 10 liters.

[0112] C. Adsorption and ...

Embodiment 2

[0116] Embodiment 2 (raw material is Vitex fringa fruit)

[0117] (A) Put 10 kg of Vitex spica into a container, add 80 liters of 20% ethanol solution to the container, heat the mixture to 85° C., keep it warm for 1.5 hours, and filter the residue to get the solution.

[0118] (B) Add 60 liters of 20% ethanol solution to the residue filtered out in step A (A), and heat the mixture of the two to 85° C., keep it warm for 1 hour, and take the liquid from the filter residue.

[0119] (C) Add 60 liters of 20% ethanol solution to the residue filtered out in step A (B), and heat the mixture of the two to 85° C., keep it warm for 1 hour, and take the liquid from the filter residue.

[0120] B. Liquid Concentration

[0121] The liquids prepared by each of the A steps (A), (B) and (C) were mixed together and then concentrated under reduced pressure until concentrated to 10 liters.

[0122] C. Adsorption and elution

[0123] The concentrated extract is dissolved in 75% ethanol, and th...

Embodiment 3

[0126] Embodiment 3 (raw material is vitex)

[0127] A. Herbal decoction

[0128] (A) Put Vitex 10kg pulverized into the container, then add 80 liters of 90% ethanol solution to the container, then heat the mixture of the two to 70°C, keep it warm for 1.5 hours, and take the liquid from the filter residue.

[0129] (B) Add 60 liters of 90% ethanol solution to the residue filtered out in step A (A), and heat the mixture of the two to 70° C., keep it warm for 1 hour, and take the liquid from the filter residue.

[0130] (C) Add 60 liters of 90% ethanol solution to the residue filtered out in step A (B), and heat the mixture of the two to 70° C., keep it warm for 1 hour, and take the liquid from the filter residue.

[0131] B. Liquid Concentration

[0132] The liquids prepared by each of the A steps (A), (B) and (C) were mixed together and then concentrated under reduced pressure until concentrated to 10 liters.

[0133] C. Adsorption and elution

[0134] The concentrated ext...

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Abstract

The invention relates to a novel medicinal use of negundo chastetree fruits, the process for preparing the pharmaceutical intermediate compounds, and the use of the medicament in preparing pharmaceuticals for resisting tumor and suppressing osteoporosis.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine extraction process and its pharmaceutical preparation, and also includes the application of the medicine of the invention in the preparation of anti-tumor and osteoporosis-inhibiting medicines. Background technique: [0002] There are about 250 species of Verbenaceae trees or shrubs in the genus Vitex, which are mainly distributed in tropical and temperate regions. In my country, there are 14 species, 7 subspecies, and 3 species are mainly produced in the south of the Yangtze River. There are 7 medicinal species in my country, namely: V. canescens, V. negundo, V. trifolia, V. rotundifolia, V. agnus-castus, and V. agnus-castus. V.peduncularis and V.quinata. [0003] The main components contained in Vitex extracts are one or more of the following table: Table 1. [0004] [0005] Modern pharmacological studies have shown that some plants in this genus or their components have the effects of ana...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61K31/7028A61P35/00A61P19/10
Inventor 周应军申璀曾光尧谭健兵谭桂山徐康平李福双
Owner CHANGSHA SANYOU PHARMA
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