Surface-active substance composition moireuphe and method for preparing the same and use thereof
A surfactant and composition technology, applied in the application field of surfactant composition and preparation of drugs for the treatment of pulmonary surfactant deficiency, can solve problems such as reducing surface tension
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[0021] A kind of preparation method of surface-active substance composition Moryuffi, the steps are as follows:
[0022] The biological tissue of frozen marine shellfish is crushed, solvent extraction is carried out at room temperature, the extract is filtered, the filtrate is concentrated under reduced pressure and evaporated to remove the organic solvent, then the purification agent is added for extraction treatment, the upper layer is collected and concentrated to a certain volume , decolorized, and then concentrated under reduced pressure to obtain a surface active substance (SAS), then add distilled water and heparin, and finally freeze-dry under low pressure to obtain a freeze-dried powder.
[0023] Preferably, in the above-mentioned preparation method, after the decolorization treatment, vitamin E is added first, so that the weight percentage of vitamin E in the final product composition is 0.01-0.5%, and then concentrated under reduced pressure, which can protect the co...
Embodiment 1
[0085] Embodiment 1: 100g of frozen marine mussel tissue, minced by a meat grinder, placed in an extraction vessel with stirring, added 10 times the volume of ethanol, extracted for 2 hours, filtered, the filtrate was vacuum recovered solvent, and the filtered raw material was used Acid ethanol (adjust pH ≥ 4 with acetic acid) and extract for another 1 hour. Combine the extracts, filter, evaporate the solvent in vacuo, redissolve with ethanol, and add a mixture of n-hexane and ethyl acetate, the volume ratio of ethanol:n-hexane:ethyl acetate is 10:20:1, separate n-hexane- Ethyl acetate layer, vacuum concentrated to 1 / 10 volume, add activated carbon, filter with 0.2um microporous membrane to remove residual protein components, add vitamin E to the ethyl acetate filtrate, make vitamin E in the final product combination The weight percentage in the product was 0.2%, concentrated under reduced pressure, added 0.1% heparin, and freeze-dried to obtain a pharmaceutical preparation wi...
Embodiment 2
[0086] Embodiment 2: 100 grams of frozen squid, minced by a meat grinder, placed in an extraction container with stirring, added 10 times the volume of ethanol, extracted for 2 hours, filtered, the filtrate vacuum recovery solvent, and the filtered raw material was used with acidic ethanol ( Acetic acid to adjust pH ≥ 4) and then extract for 1 hour, combine the extracts, filter, evaporate the solvent in vacuo, redissolve with ethanol, and add a mixture of acetone and ethyl acetate, the volume ratio of ethanol: n-hexane: ethyl acetate is 10 : 20:1, separate the acetone-ethyl acetate layer, concentrate in vacuo to 1 / 10 volume, add activated carbon, filter with a 0.2um microporous membrane to remove the remaining protein components, in the acetone-ethyl acetate filtrate Add vitamin E so that the weight percentage of vitamin E in the final product composition is 0.5%, concentrate under reduced pressure, add 0.1% heparin, and freeze-dry to obtain a pharmaceutical preparation with a ...
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