Surface-active substance composition moireuphe and method for preparing the same and use thereof

A surfactant and composition technology, applied in the application field of surfactant composition and preparation of drugs for the treatment of pulmonary surfactant deficiency, can solve problems such as reducing surface tension

Active Publication Date: 2008-01-30
BIOLOGY INST OF SHANDONG ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some studies have reported that some drugs containing hydrated soybean lecithin (phospholipon-90 H) have surface activity, but in fact, the ability of these drugs to reduce surface tension is not as good as people imagined

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0021] A kind of preparation method of surface-active substance composition Moryuffi, the steps are as follows:

[0022] The biological tissue of frozen marine shellfish is crushed, solvent extraction is carried out at room temperature, the extract is filtered, the filtrate is concentrated under reduced pressure and evaporated to remove the organic solvent, then the purification agent is added for extraction treatment, the upper layer is collected and concentrated to a certain volume , decolorized, and then concentrated under reduced pressure to obtain a surface active substance (SAS), then add distilled water and heparin, and finally freeze-dry under low pressure to obtain a freeze-dried powder.

[0023] Preferably, in the above-mentioned preparation method, after the decolorization treatment, vitamin E is added first, so that the weight percentage of vitamin E in the final product composition is 0.01-0.5%, and then concentrated under reduced pressure, which can protect the co...

Embodiment 1

[0085] Embodiment 1: 100g of frozen marine mussel tissue, minced by a meat grinder, placed in an extraction vessel with stirring, added 10 times the volume of ethanol, extracted for 2 hours, filtered, the filtrate was vacuum recovered solvent, and the filtered raw material was used Acid ethanol (adjust pH ≥ 4 with acetic acid) and extract for another 1 hour. Combine the extracts, filter, evaporate the solvent in vacuo, redissolve with ethanol, and add a mixture of n-hexane and ethyl acetate, the volume ratio of ethanol:n-hexane:ethyl acetate is 10:20:1, separate n-hexane- Ethyl acetate layer, vacuum concentrated to 1 / 10 volume, add activated carbon, filter with 0.2um microporous membrane to remove residual protein components, add vitamin E to the ethyl acetate filtrate, make vitamin E in the final product combination The weight percentage in the product was 0.2%, concentrated under reduced pressure, added 0.1% heparin, and freeze-dried to obtain a pharmaceutical preparation wi...

Embodiment 2

[0086] Embodiment 2: 100 grams of frozen squid, minced by a meat grinder, placed in an extraction container with stirring, added 10 times the volume of ethanol, extracted for 2 hours, filtered, the filtrate vacuum recovery solvent, and the filtered raw material was used with acidic ethanol ( Acetic acid to adjust pH ≥ 4) and then extract for 1 hour, combine the extracts, filter, evaporate the solvent in vacuo, redissolve with ethanol, and add a mixture of acetone and ethyl acetate, the volume ratio of ethanol: n-hexane: ethyl acetate is 10 : 20:1, separate the acetone-ethyl acetate layer, concentrate in vacuo to 1 / 10 volume, add activated carbon, filter with a 0.2um microporous membrane to remove the remaining protein components, in the acetone-ethyl acetate filtrate Add vitamin E so that the weight percentage of vitamin E in the final product composition is 0.5%, concentrate under reduced pressure, add 0.1% heparin, and freeze-dry to obtain a pharmaceutical preparation with a ...

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Abstract

The present invention relates to a surfactant moryoupe and the preparation method and the application of the surfactant, which pertains to the technical field of pharmaceutical industry. The composition is made by extraction, purification and other steps of the tissues of bivalves mollusks, the composition contains rich phospholipid complex of the seafood which is composed of polyunsaturated fatty acids, wherein, the composition includes plasmalogen, active short-chain peptides and amino acids etc. The composition of the present invention has the surface activity of the surfactant, which can be used for preparing the drugs for replacement, therapy during the lack of pulmonary surfactants; furthermore, the invention has no immunogenicity.

Description

technical field [0001] The invention relates to a surfactant composition obtained from marine mollusk organs - "Moryuffi" and its preparation method, and its application in the preparation of drugs for treating pulmonary surfactant deficiency, belonging to the field of pharmaceutical industry. Background technique [0002] Insufficient pulmonary surfactant secreted by alveolar epithelial cells will lead to serious pulmonary pathological phenomena, such as respiratory disorder, atelectasis, edema, etc. causing pneumonia, cardiopulmonary valve insufficiency, etc. One theory is that the low prevalence of lung disease in Eskimos is due to their diet rich in omega-3 unsaturated fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid ( DHA) has good health care and disease prevention functions. EPA and DHA are easily oxidized and deteriorated if they are free, but they can become stable if vitamin E is present at the same time, see Song J.H., Jhoul Y., Miyazawa ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/56A61P11/00A61K35/618
Inventor 刘可春考米沙林科·谢尔盖达特森科·卓娅契克曼·伊万莫伊谢耶娃·柳米拉考赳米拉·奥丽娜别列别杰夫·吉纳迪韩利文康尼维特·娜塔丽娅
Owner BIOLOGY INST OF SHANDONG ACAD OF SCI
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