Use of steroid hormone synthesized acute regulation protein in the preparation of medicament for preventing and controlling fatty liver

A technology of steroid hormones and regulatory proteins, which is applied in the biological field and can solve problems such as limitations and effects that have not been reported.

Inactive Publication Date: 2008-03-05
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The research on StAR in the prior art is limited to the synthesis tissue of steroid h...

Method used

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  • Use of steroid hormone synthesized acute regulation protein in the preparation of medicament for preventing and controlling fatty liver
  • Use of steroid hormone synthesized acute regulation protein in the preparation of medicament for preventing and controlling fatty liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] 1. Establish a mouse model of hyperlipidemia

[0051] Mouse feeding: apoE gene knockout mice and C57BL / 6J mice with the same genetic background were kept in a clean-grade animal room with a room temperature of 22°C and a relative humidity of 55%. They were fed with normal rodent diet and free to eat and drink .

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Abstract

The present invention belongs to the field of biotechnology, and is especially the application of acute regulating protein synthesized with steroid hormone in the medicine for reducing lipidosis in liver cell. Experiments show that mouse with apoE gene knockout has obviously raised blood fat compared with C57BL/6J mouse in the same genetic background and the liver tissue of mouse with StAR gene virus has obviously lowered triglyceride and cholesterol contents and less lipoids, and proves that acute regulating protein synthesized with steroid hormone has effect of lowering lipidosis in liver cell and may be applied in preparing medicine for reducing lipidosis in liver cell. The present invention provides evidence for developing clinical way to treating fatty liver and other diseases caused by lipoid metabolizing disturbance.

Description

technical field [0001] The invention belongs to the field of biological technology, and relates to a new application of a cholesterol transporter-steroid hormone-synthesized acute regulatory protein, in particular to the use of a steroid-hormone-synthesized acute regulatory protein in drugs for reducing fat deposition in liver cells. Background technique [0002] Fat deposition in the liver is a serious complication caused by lipid metabolism disorder. If the lipid metabolism disorder cannot be corrected in time, it will further develop into fatty liver, liver fibrosis and liver cirrhosis, which will seriously affect people's quality of life. According to relevant statistics, the incidence of fatty liver in patients with severe hypertriglyceridemia and mixed hyperlipidemia is 5-6 times higher than that of normal people. Normally, the liver absorbs free fatty acids and converts them into triglycerides, which are then combined with specific apolipoproteins to form very low-den...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61P1/16
Inventor 殷莲华宁艳霞陈思锋陆超任顺林赵凤娣
Owner FUDAN UNIV
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