Hydrochloric acid olprinone injection and method for preparing the same

Abstract

The present invention discloses a stable hydrochloride olprinone injection which is used for curing acute heart failure. The present invention comprises a drug active ingredient of hydrochloride olprinone, an acid-base buffer system and water-soluble excipient. The present invention is used for curing acute heart failure.

Description

technical field [0001] The invention relates to an injection for treating acute heart failure, in particular to an injection of octoprenone hydrochloride. Background technique [0002] Heart failure, also known as congestive heart failure, refers to a syndrome in which the blood output is reduced due to primary heart damage and cannot meet the needs of tissue metabolism under the condition of normal venous return. Clinically, pulmonary circulation and / or Systemic circulation congestion and tissue hypoperfusion are the main features. With the advancement of cardiovascular disease diagnosis and treatment technology, many diseases with high acute mortality, such as acute myocardial infarction, have greatly reduced early mortality due to the use of thrombolysis and other treatment methods, but on the contrary, the incidence of heart failure has increased year by year. In addition, as human life continues to prolong, myocardial aging has also become an important cause of heart f...

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Problems solved by technology

US6156753 and US2002037827 disclose the application of oxyprinone hydrochloride in male erectile dysfunction. The administration routes are oral administration, topical administration, and transdermal administration. Slow, irritating, and easy to contaminate clothes, so the current research work is devoted to the research and development of intravenous injection