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Hydrochloric acid olprinone injection and method for preparing the same

A technology of Oprinone hydrochloride and non-nong injection, which is applied in the direction of medical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve the problem of high irritation, easy to pollute clothes, and slow onset of action. and other problems, to achieve good stability, simple and applicable preparation method

Inactive Publication Date: 2008-04-02
BEIJING D VENTUREPHARM TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

US6156753 and US2002037827 disclose the application of oxyprinone hydrochloride in male erectile dysfunction. The administration routes are oral administration, topical administration, and transdermal administration. Slow, irritating, and easy to contaminate clothes, so the current research work is devoted to the research and development of intravenous injection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 6

[0067] Embodiment 6: The long-term stability test result of the sample prepared according to embodiment 2 is shown in the table below

[0068] time

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PUM

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Abstract

The present invention discloses a stable hydrochloride olprinone injection which is used for curing acute heart failure. The present invention comprises a drug active ingredient of hydrochloride olprinone, an acid-base buffer system and water-soluble excipient. The present invention is used for curing acute heart failure.

Description

technical field [0001] The invention relates to an injection for treating acute heart failure, in particular to an injection of octoprenone hydrochloride. Background technique [0002] Heart failure, also known as congestive heart failure, refers to a syndrome in which the blood output is reduced due to primary heart damage and cannot meet the needs of tissue metabolism under the condition of normal venous return. Clinically, pulmonary circulation and / or Systemic circulation congestion and tissue hypoperfusion are the main features. With the advancement of cardiovascular disease diagnosis and treatment technology, many diseases with high acute mortality, such as acute myocardial infarction, have greatly reduced early mortality due to the use of thrombolysis and other treatment methods, but on the contrary, the incidence of heart failure has increased year by year. In addition, as human life continues to prolong, myocardial aging has also become an important cause of heart f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/437A61K47/12A61P9/04
Inventor 岳本花
Owner BEIJING D VENTUREPHARM TECH DEV
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