Transdermal drug delivery preparation containing arteannuin or its derivant and use of the same

A derivative of artemisinin, artemisinin technology, applied in the field of medicine, can solve the problem of malaria parasite resurgence

Active Publication Date: 2011-05-11
BEIJING ZHONGYAN TONGRENTANG CHINESE MEDICINE R & D
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the above problems, the present inventors researched and developed artemisinin and its derivatives as active ingredients, and prepared it into an in vitro transdermal drug delivery system, so as to realize the percutaneous absorption of artemisinin and its derivatives, avoiding the first Over-effect, long-term maintenance of effective blood concentration, successfully solved the problem of resurgence of malaria parasites

Method used

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  • Transdermal drug delivery preparation containing arteannuin or its derivant and use of the same
  • Transdermal drug delivery preparation containing arteannuin or its derivant and use of the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Mix 80g of artemisinin, 100g of PEG400, grind evenly, then add 800g of acrylate pressure-sensitive adhesive, 45g of azone, mix evenly, apply on the backing with a coating machine, dry, compound with a protective film, and die-cut.

Embodiment 2

[0031] Dissolve 200g of artemether in 800g of acrylate pressure-sensitive adhesive, add 56g of N-methyl-2-pyrrolidone, mix well, apply on the backing with a coating machine, dry, compound with a protective film, and die-cut to obtain .

Embodiment 3

[0033] Dissolve 50g of dihydroartemisinin in 800g of polyisobutylene pressure-sensitive adhesive, add 50g of oleic acid, mix evenly, apply on the backing with a coating machine, dry, compound with a protective film, and die-cut.

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Abstract

The invention discloses a transdermal drug delivery compound formula containing artemisinin or the derivatives of artenisinin. The compound cures malaria by way of ransdermal drug delivery and effectively prevents the recrudescence of plasmodium. The transdermal drug delivery compound of the invention contains recrudenscence or the derivatives of recrudescence, medium, latent solvent and transdermal enhancer. The transdermal drug delivery compound of the invention treats in vitro through skin, avoids the first pass effect of liver and the blood drug concentration is stationary and the use is convenient. Animal experiments prove that the transdermal drug delivery compound is capable of effectively killing plasmodium and has the function of effective anti-recrudescence. Besides, the stimulation to skin is little without causing allergy or toxicity.

Description

【Technical field】 [0001] The invention belongs to the technical field of medicine, and relates to a transdermal preparation containing artemisinin or a derivative thereof, a preparation method and application thereof. 【Background technique】 [0002] Artemisinin derivatives are powerful antimalarial drugs commonly used in clinical practice. When malaria parasites are severely resistant to drugs such as chloroquine and facida, artemisinin derivatives have excellent antimalarial effects and have a positive effect on brain-type malaria. Falciparum malaria such as malaria has a good therapeutic effect, and has no toxic and side effects, and is an ideal fast-acting, low-toxic malaria treatment drug. [0003] However, when artemisinin and its derivatives, especially artemisinin, are administered orally in tablets and capsules, there is a hepatic first-pass effect. In order to avoid the first-pass effect, pharmacists try to use suppositories for rectal administration and Injection ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K31/357A61K31/365A61P33/06
CPCA61K9/7053A61K9/7061A61K31/357A61K31/366A61P33/06Y02A50/30
Inventor 叶祖光王乃婕张志慧
Owner BEIJING ZHONGYAN TONGRENTANG CHINESE MEDICINE R & D
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