Bracket for controlling releasing and elution of tranilast medicament coating

A drug-coating and stent-eluting technology, applied in the fields of coatings, stents, medical science, etc., can solve the problems of sensitization, delayed stent endothelialization, and inflammation, and achieve the effect of uniform distribution

Inactive Publication Date: 2008-05-21
SHANGHAI PUTUO DISTRICT CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The coating of drug-eluting stents in clinical application is mainly a single-coat or double-coat structure composed of a drug-loaded layer and / or a controlled-release layer. This coating structure has good drug-controlled release performance and stable Physical and chemical properties, but there are adverse effects such as sensitization, inflammation, and delayed stent endothelialization, and there are no defects such as antithrombotic effect

Method used

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  • Bracket for controlling releasing and elution of tranilast medicament coating
  • Bracket for controlling releasing and elution of tranilast medicament coating
  • Bracket for controlling releasing and elution of tranilast medicament coating

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: Preparation of drug-containing layer coating

[0031] Take 300 mg of butyl methacrylate / nano-silicon dioxide and 35 mg of tranilast, dissolve it by vortexing with tetrahydrofuran and set the volume to 10 ml to prepare a drug-containing layer coating solution. Then use a spray pen to spray the coating solution on the bottom layer of the stent, and after standing at room temperature for 10 minutes, repeat the above steps until the required weight is reached, and then vacuum dry at 30°C for 12 hours to prepare the drug-containing layer coating.

Embodiment 2

[0032] Embodiment 2: Preparation of drug-containing layer coating

[0033] Take 300mg of butyl methacrylate / nano-silicon dioxide and 200mg of tranilast, dissolve it with tetrahydrofuran by vortexing and set the volume to 10ml, and prepare the drug-containing layer coating liquid. Then use a spray pen to spray the coating solution on the bottom layer of the stent, and after standing at room temperature for 10 minutes, repeat the above steps until the required weight is reached, and then vacuum dry at 30°C for 12 hours to prepare the drug-containing layer coating.

Embodiment 3

[0034] Embodiment 3: prepare drug-containing layer coating

[0035] Take 300mg of butyl methacrylate / nano-silicon dioxide and 450mg of tranilast, vortex dissolve with tetrahydrofuran and set the volume to 10ml to prepare the drug-containing layer coating solution. Then use a spray pen to spray the coating solution on the bottom layer of the stent, and after standing at room temperature for 10 minutes, repeat the above steps until the required weight is reached, and then vacuum dry at 30°C for 12 hours to prepare the drug-containing layer coating.

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PUM

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Abstract

The invention relates to a tranilast medicine coat controlled release eluting bracket, pertaining to the field of medicine and medical appliance. The invention takes tranilast as the active component;three layers of a medicine loading layer, a controlled release layer and a protecting film layer are at the surface of the bracket. The bracket coat is evenly distributed on the surface of the bracket without crack and exfoliating phenomena; the original morphological structure can be kept after expanding. Proved by animal experiment result, the invention can effectively restrain the coronary hyperplasia and restenosis and markedly reduce the function of restraining the blood vessel endothelial cell at the same time; compared with the single coat or double coat structure of the existing drug-eluting bracket, the bracket of the invention can prevent the restenosis of the bracket, and has the functions of prventing bracket thrombus from being formed and promoting the early reparation of thebracket endothelium.

Description

technical field [0001] The invention belongs to the field of drugs and medical devices, and relates to a cardiovascular drug-eluting stent, in particular to a tranilast drug-coated controlled-release eluting stent. Background technique [0002] Cardiovascular disease represented by coronary atherosclerosis is currently the greatest threat to human health. According to relevant statistics, millions of people in my country suffer from coronary heart disease and other vascular stenosis diseases every year. At present, the commonly used treatment methods include oral drug treatment, surgical treatment and interventional treatment. Among them, cardiac interventional therapy represented by percutaneous transluminal angioplasty (PTCA) and stent implantation has the advantages of small trauma, fast recovery, and can deliver drugs to the lesion in a targeted manner, which enhances the effect of drug therapy and reduces the systemic risk of drugs. The advantages of toxicity and side ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/16A61L31/10A61F2/82A61K31/196
Inventor 刘宗军金惠根罗启剑秦永文彭文钟伟于文
Owner SHANGHAI PUTUO DISTRICT CENT HOSPITAL
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