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Rapid magnetic biosensor with integrated arrival time measurement

A magnetic sensor, time-of-arrival technology, used in measurement devices, instruments, scientific instruments, etc., to achieve rapid determination, reduce time to results, improve detection limits, and specificity

Inactive Publication Date: 2008-06-11
KONINKLIJKE PHILIPS ELECTRONICS NV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Since the target molecule to be detected in the fluid sample is low concentration (for example pmol.l -1 The background material that changes with the following) is high concentration (for example mmol.l -1 ), presents challenges in biochemical assays

Method used

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  • Rapid magnetic biosensor with integrated arrival time measurement
  • Rapid magnetic biosensor with integrated arrival time measurement
  • Rapid magnetic biosensor with integrated arrival time measurement

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Embodiment Construction

[0038] The present invention will be described with respect to particular embodiments and with reference to certain drawings but the invention is not limited thereto but only by the claims. The drawings are only schematic and non-limiting. In the drawings, the size of some of the elements is exaggerated and not drawn on scale for illustrative purposes.

[0039] Where an indefinite or definite article is used with reference to a singular noun eg "a", "the", this includes a plural of that noun unless something else is specifically stated.

[0040] Furthermore, the terms first, second, third etc. in the description and claims are used to distinguish between analogs and not necessarily to describe a sequential or chronological order. It is to be understood that the terms so used are interchangeable under appropriate circumstances and that the embodiments of the invention described herein are capable of operation in other sequences than described or illustrated herein.

[0041] A...

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Abstract

The invention provides a method, a device and a system for determining a concentration of at least one sort of polarizable or polarized magnetic labels in a fluid, the sensing surface comprising at least one sort of binding sites capable of specifically attaching to at least one sort of biological entities linked to the magnetic labels, the sensing device further comprising at least one magnetic sensor element, the sensing device further comprising first means for determining the concentration of magnetic labels attached to the binding sites and second means for determining the time of arrival of the fluid.

Description

technical field [0001] The invention relates to a sensing device and a system for determining the concentration of at least one polarizable or polarized magnetic label in a liquid, comprising the sensing device. The invention still further relates to a method for determining the concentration of at least one polarizable or polarized magnetic label in a liquid using a sensing device. Background technique [0002] In the field of diagnostics, especially biomedical diagnostics, such as pharmaceutical and food diagnostics for in vivo and in vitro use, the use of biosensors or biochips is well known. These biosensors or biochips are usually used in the form of biochip microarrays that enable the analysis of biological entities such as DNA (deoxyribonucleic acid), RNA (ribonucleic acid), proteins or e.g. hormones or Small molecules of drugs. Currently, there are various assays for analyzing small quantities of biological entities or biomolecules or fragments of biological entiti...

Claims

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Application Information

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IPC IPC(8): G01N33/543
CPCG01N27/745G01N33/54333
Inventor M·W·J·普林斯
Owner KONINKLIJKE PHILIPS ELECTRONICS NV
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