Pennogenyl Saponins percutaneous-absorping preparation

Abstract

The invention relates to a special preparation with pennogenyl saponins as the active component. The percutaneous absorption preparation of the pennogenyl saponins is composed of the following ingredients based on weight percentage: 0.05-40% of pennogenyl saponins, 1-20% of penetration enhancer, and 40-98.5% of medicine substrate. The pennogenyl saponins of the invention has strong activity; the daily dose of medicine is only 1 to 10 mg; as long as five to ten percent of the pennogenyl saponins is absorbed into the blood, the pennogenyl saponins can play its role, so the pennogenyl saponins is very suitable for producing percutaneous preparation. The patient can freely control the dose time and no gastrointestinal adverse reaction will be caused by the pennogenyl saponins. The pennogenyl saponins can be made into cream, cataplasm, coating agent and aerosol due according to different drug substrates.

Description

Transdermal absorption preparation of pinanoside compounds This application is a divisional application of 200510010928.9. The filing date of the original application is July 22, 2005, and the application number is 200510010928.9. The name of the invention is: transdermal absorption preparation of pinanoside compounds. technical field The invention relates to a special preparation form with pinanoside compounds as active ingredients. Background technique The distribution of pinanosides in the plant kingdom is not very wide, and the content is relatively low. Chinese patent application No. 02150907.7 discloses a "17-hydroxy C#-[27] steroid compound, its synthesis method and its use", which can be used for the synthesis of pinanoside compounds. Chinese patent 03135589.7 discloses the purification of pinanoside compounds. Chinese Patent No. 85108520 discloses the application of two pinanoside compounds in gynecological anemia. Pharmacokinetic studies have shown that the b...

AI Technical Summary

Problems solved by technology

Pharmacokinetic studies have shown that the bioavailability of pinanoside compounds is extremely low, and more than 90% of them are excreted from the feces via the gastrointestinal tract in the original form. The main adverse reaction is gastrointestinal discomfort

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