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Liquid crystal hydroxyl apatite/polymer compound aeolotropy bone substitute material and preparing method thereof

A hydroxyapatite, anisotropic technology, used in medical science, prosthesis, etc.

Inactive Publication Date: 2008-06-18
TIANJIN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

And make n-HA uniform, the preparation method of the n-HA / polymer biomimetic bone repair material of orientation distribution and the prepared material have not been reported at home and abroad

Method used

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  • Liquid crystal hydroxyl apatite/polymer compound aeolotropy bone substitute material and preparing method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: A preparation method of liquid crystal hydroxyapatite / polymer composite anisotropic bone substitute material, characterized in that it comprises the following steps:

[0023] (1) Polyamide (PA66) is dissolved in the organic solvent cyclohexane;

[0024] (2) Take an appropriate amount of n-HA liquid crystal according to the design ratio, stir and blend with PA66 solution at 50°C for 3 hours, and make the liquid crystal n-HA particles uniformly aligned in PA66 under the action of the stirring force field;

[0025] (3) heating the blended solution to 140° C. to volatilize the organic liquid and concentrate the mixed solution;

[0026] (4) Put the miscible concentrate into -10°C for quick freezing for 5 hours to fix the orderly arrangement of n-HA in the polymer;

[0027] (5) Freeze the residual organic solvent under atmospheric conditions, and then dry at 40° C. for 24 hours in a thermostat;

[0028] (6) Using a hot-press forming machine, hot-press at 280° ...

Embodiment 2

[0030] Embodiment 2: A preparation method of liquid crystal hydroxyapatite / polymer composite anisotropic bone substitute material, characterized in that it comprises the following steps:

[0031] (1) Polyurethane (PU) is dissolved in the organic solvent acetic acid;

[0032] (2) Take an appropriate amount of n-HA liquid crystal according to the design ratio, stir and blend with the PU solution for 3 hours at 60°C, and under the action of the stirring force field, make the liquid crystal n-HA particles uniformly aligned in PA66;

[0033] (3) heating the blended solution to 160°C to volatilize the organic liquid and concentrate the mixed solution;

[0034] (4) Put the miscible concentrate into -10°C for quick freezing for 5 hours to fix the orderly arrangement of n-HA in the polymer;

[0035] (5) Freeze the residual organic solvent under atmospheric conditions, and then dry at 40° C. for 24 hours in a thermostat;

[0036] (6) Using a hot-press forming machine, hot-press at 280...

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Abstract

Disclosed is a liquid crystal hydroxyapatite / polymer compounded anisotropic bone-substituted material and the preparation method, including the following steps: (1) dissolve hydrophilic macromolecule polymer with polarity into organic solvent; (2) mix together with proper n-HA liquid crystal to have liquid crystal n-HA particles arranged evenly in the polymer; (3) heat the mixing liquid to volatilize organic liquid; (4) freeze the condensate of the mixing liquid under a super-low temperature to fix the orderly arrangement of n-HA in the polymer; (5) dry for 24 hours; (6) after hot briquetting, get n-HA / polymer biological composites. The n-HA is stick-shaped liquid crystal particles with the diameter of 12-20nm and the length of 200-300nm and distributes evenly in polymer basal body along certain direction, so that the mechanical property along the n-HA arranging direction is optimized greatly, that is, the bionical simulation of the natural bone is achieved from the aspects of component, texture and performance. Thereby, the using requirement for clinic load-bearing bone material can be satisfied.

Description

(1) Technical field: [0001] The invention belongs to the preparation technology of inorganic / organic biocomposite materials, in particular to a technology for preparing bone repair substitute materials with anisotropic properties by utilizing the high fluidity and easy orientation of hydroxyapatite liquid crystals under the action of an external force field. (two) background technology: [0002] Human bones and teeth are natural composite materials composed of nano-hydroxyapatite needle crystals (n-HA) arranged in order on collagen fibers, which have excellent mechanical properties. In recent years, with the goal of biomimetic biological structure and function, research on nano-hydroxyapatite and polymer composite bone repair materials has become a hot spot. [0003] Looking at the research at home and abroad, the developed composite materials have their own characteristics, but there are also certain problems. For example: the high molecular weight polyethylene / HA composit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46
Inventor 陈民芳由臣刘德宝沈荣臻
Owner TIANJIN UNIVERSITY OF TECHNOLOGY
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