Methods and compositions for treating pain
A composition and compound technology, applied in the directions of drug combinations, active ingredients of heterocyclic compounds, pharmaceutical formulations, etc., can solve the problems such as frequency and intensity of pain at the injection site, and no disclosure of phlebitis.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment approach
[0156]Administer intramuscularly. Once a common method of administration, the intramuscular (IM) route is less commonly used than it used to be due to improved oral drug availability and the convenience of intravenous administration. This method of administration involves injecting the drug directly into the muscle tissue, where the drug is gradually absorbed throughout the body. For intramuscular administration of non-stimulating drugs requiring only a single injection, the intramuscular route remains a viable route, especially in outpatient settings. The intravenous route is preferred when repeated dosing is required or when rapid and reliable onset of action is desired, since repeated intramuscular administration is painful and inconvenient. Typically, the deltoid, gluteus maximus, and vastus lateralis are the sites used for intramuscular injections.
[0157] Subcutaneous injection. Subcutaneous injections involve injection into the fatty tissue under the skin. The meth...
Embodiment 1
[0302] Ketoprofen-piperazine (1:2) complex
[0303] An aqueous mixture of 0.5M ketoprofen and 1.0M piperazine was sonicated until a clear solution was obtained. The solution was then filtered through a 0.45 micron syringe filter (the pH of the filtered aliquot was approximately 10.00). Small aliquots (approximately 0.250 mL) were placed in 12-well spot ceramic plates. The physical mixture precipitated out within a few days (2-3 days) at ambient temperature.
[0304] The ketoprofen-piperazine complex forms a semisolid (physical mixture) with a water solubility greater than 360 mg / mL and a pH of approximately 9.4 (for a saturated solution).
Embodiment 2
[0306] Ketoprofen-ethylenediamine (1:2) complex
[0307] A mixture of 0.5M ketoprofen and 1.0M ethylenediamine was sonicated until a clear solution was obtained. The solution was then filtered through a 0.45 micron syringe filter (the pH of the filtered aliquot was approximately 10.00). Small aliquots (approximately 0.250 mL) were placed in 12-well spot ceramic plates. The physical mixture precipitated out within a few days (2-3 days) at ambient temperature.
[0308] The ketoprofen-ethylenediamine complex forms a semi-solid form with a water solubility greater than 500 mg / mL and a pH of about 7.3 (for a saturated solution).
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More