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Use of hederagenin and its derivatives in preparing antidepressant product

A technology of helexin and ivy soap, applied in the fields of medicine and food, can solve the problem of preventing, diagnosing, detecting, protecting, treating and researching depression and its directly related diseases that have not yet been found helexin and its derivatives reports, etc.

Inactive Publication Date: 2011-05-04
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0067] According to literature search, so far, no reports on the use of helexin and its derivatives in the prevention, diagnosis, detection, protection, treatment and research of depression and its directly related diseases have been found.

Method used

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  • Use of hederagenin and its derivatives in preparing antidepressant product
  • Use of hederagenin and its derivatives in preparing antidepressant product
  • Use of hederagenin and its derivatives in preparing antidepressant product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0151] Embodiment 1, the preparation of Fructus Prechiae total saponins tablet

[0152] prescription:

[0153] Total Saponins of Presage Seeds 50g

[0154] Starch 30g

[0155] Lactose 40g

[0156] Sodium carboxymethyl starch 5g

[0157] Appropriate amount of starch slurry (7%)

[0158] Magnesium Stearate 1% (1.45g)

[0159] Made into 1000 pieces

[0160] Process:

[0161] Take the prescription amount of total saponins of Chizhizizi, crush it through a 100-mesh sieve, then crush the prescription amount of starch and lactose through a 100-mesh sieve, and mix well. Add the total saponins of the pre-knowledge seed into the mixed starch and lactose, and mix well. Add an appropriate amount of 50% ethanol and mix well, granulate through a 16-mesh wire mesh, dry below 60°C, granulate, add an appropriate amount of magnesium stearate, mix evenly, analyze the content and then compress into tablets. It can be made into 1,000 tablets each containing 50 mg of total ...

Embodiment 2

[0162] Embodiment 2, the preparation of aketoside D capsules

[0163] prescription:

[0164] Aketoside D 50g

[0165]Starch 140g

[0166] Micronized silica gel 10g

[0167] Make 1000 capsules

[0168] Process:

[0169] Take the prescribed amount of aketoside D, crush it through a 100-mesh sieve, add the prescribed amount of starch and micropowdered silica gel, mix well, and directly pack it into capsules to make 1000 capsules each containing 50 mg aketoside D.

Embodiment 3

[0170] Embodiment 3, the preparation of helexin capsules

[0171] prescription:

[0172] Helexin 50g

[0173] Starch 140g

[0174] Micronized silica gel 10g

[0175] Make 1000 capsules

[0176] Process:

[0177] Get the prescription amount of hedera saponin, crush through a 100-mesh sieve, add the prescription amount of starch and micropowder silica gel, mix evenly, and directly pack into capsules to make 1000 capsules each containing 50 mg hedera saponin.

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PUM

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Abstract

The present invention relates to a novel purpose of hederagenin and a derivative of the hederagenin. An anti-depression test of the hederagenin and the derivative of the hederagenin shows obvious anti-depression activity, wherein, the salt derivative of the hederagenin has stronger anti-depression activity than the hederagenin; the hederagenin has stronger anti-depression activity than hederangenoside; the activities of the hederagenin and a hypericum extract are equivalent; sodium hederagenin has higher activity than the hypericum extract. The present invention has obvious pharmacological effect and stable quality; the raw material of the present invention has abundant source and cheap price and is safe with low toxin; the present invention has simple preparation technology and high yield, which provides novel medicine source for preventing, diagnosing, examining, protecting, remedying and researching on the depression and diseases directly related to the depression, is fit for the industrialization production, is easy for popularizing and applying and has very important value for developing and using Chinese officinal plant resource. Affective mental disorder is listed at top inChinese disease general burden, and the research and manufacture of the drug for preventing and remedying the depression has obvious social benefit and economic benefit.

Description

technical field [0001] The invention relates to the technical fields of medicine and food, in particular to the application of the extract of traditional Chinese medicine, more specifically to the application of the extract of hedera saponin and its derivatives from the traditional Chinese medicine Fuzhizi to prepare antidepressant products. Background technique [0002] (1) Research overview of hedera saponin [0003] 1. Akebia [0004] Akebia is deciduous or semi-evergreen vine. Palmately compound leaves alternate, leaflets 5, obovate or long obovate, 3-6cm long, apex round, slightly concave or shortly pointed, entire. Flowers unisexual, raceme axillary; female flowers born in upper part of inflorescence, tepals 3, lavender, stamens 6, female flowers born in lower part of inflorescence, perianth 3, staminodes 6, pistils 6. The fruit is fleshy, oblong, rounded at both ends, and splits along the ventral suture when ripe. The flowering period is from April to May, and the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61P25/24
Inventor 吴耀民毛俊琴李铁军邱彦陆波
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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