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Compound red sage root extended release formulation and preparation thereof

A slow-release preparation, the technology of compound salvia miltiorrhiza, applied in the direction of medical formula, medical preparations containing active ingredients, etc., can solve the problem of balanced release of complex ingredients, to maintain effective blood drug concentration, delayed release effect

Inactive Publication Date: 2011-07-27
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the problem of balanced release of complex components of traditional Chinese medicine compound sustained-release preparations, and to develop a Chinese medicine compound Danshen sustained-release preparation that has good slow-release performance and can maintain effective blood drug concentration in the body for a long time

Method used

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  • Compound red sage root extended release formulation and preparation thereof
  • Compound red sage root extended release formulation and preparation thereof
  • Compound red sage root extended release formulation and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 Preparation of Sustained Release Tablets

[0032] (1) Embedding of borneol

[0033] Weigh 15g of natural beeswax in a water bath, heat and melt, add 15g of borneol, stir to fuse together, cool to below 10°C, crush and pass through a 20-mesh sieve to obtain 30g of borneol-embedded material;

[0034] (2) Preparation of sustained-release preparations

[0035] Weigh 15g of Salvia miltiorrhiza extract, 20g of Panax notoginseng extract, 50g of ethyl cellulose, mix well, add 18ml of 50% ethanol, granulate, dry, add 30g of borneol embedding material, 1g of magnesium stearate, mix well, and press into Compound salvia miltiorrhiza sustained-release preparation;

[0036] (3) Stomach and enteric film coating

[0037] Weigh 50g of acrylic resin I, soak it in 1000mL of 75% ethanol for 8 hours, dissolve it, add 15g of triethyl citrate, 15g of Tween 80, and 20g of titanium dioxide, stir well, pass through a 80-mesh sieve after being ground by a colloid mill. The compound ...

Embodiment 2

[0038] Example 2 Preparation of sustained-release capsules

[0039] (1) Embedding of borneol

[0040] Weigh 60g of natural beeswax in a water bath to heat and melt, add 40g of borneol, stir to fuse together, cool to below 10°C, crush and pass through a 20-mesh sieve to obtain 100g of borneol-embedded matter;

[0041] (2) Preparation of sustained-release preparations

[0042] Weigh 30g of Danshen extract, 15g of Panax notoginseng extract, 15g of ethyl cellulose, mix well, add 15ml of 50% ethanol, granulate, dry, granulate, add 1g of magnesium stearate, 100g of borneol embedding, measure Content, calculate filling volume, fill capsules.

Embodiment 3

[0043] Example 3 Preparation of Sustained Release Pills

[0044] (1) Embedding of borneol

[0045] Weigh 90g of natural beeswax in a water bath, heat and melt, add 10g of borneol, stir to fuse together, cool to below 10°C, crush and pass through a 20-mesh sieve to obtain 100g of borneol-embedded matter;

[0046] (2) Preparation of sustained-release preparations

[0047] Weigh 20g of Salvia miltiorrhiza extract, 10g of Panax notoginseng extract, 100g of borneol embedding material, 60g of hydroxypropyl methylcellulose, mix well, add 12g of PVP-k30, mix well, and directly press into sustained-release pills.

[0048] (3) Sustained-release film coating

[0049] Weigh 60g of ethyl cellulose, soak it in 500mL of 75% ethanol for 5 hours, dissolve it, add 10g of castor oil, 15g of lauryl sulfates, and 15g of polyethylene glycol, stir well, pass through a 80-mesh sieve after being ground by a colloid mill. The compound salvia miltiorrhiza preparation is spray-coated with a slow-release...

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Abstract

The present invention discloses Compound Salvia Miltiorrhiza Sustained-release Tablet. The controlled release mode includes skeleton sustained and controlled release, membrane sustained and controlled release, and skeleton-membrane sustained and controlled release. The formulation type includes troche, capsule, grain, pill, suspensions, etc. The experimental result of in vitro release of CompoundSalvia Miltiorrhiza Sustained-release Tablet provided by the present invention can effectively maintain the release for more than 8 hours and the in vitro accumulative release is in line with Higuchiequation. Compared with the conventional Compound Salvia Miltiorrhiza Tablet, the present invention can delay the drug release and maintain the effective plasma concentration for a long time.

Description

[0001] The original application number of this application is 200510100535.7, the application date is October 27, 2005, and the invention name is: a compound salvia miltiorrhiza slow-release preparation and its preparation method. technical field [0002] The invention relates to a traditional Chinese medicine compound slow-release preparation and a preparation method thereof, in particular to a compound salvia miltiorrhiza slow-release preparation with skeleton slow-release, membrane-controlled slow-release, and skeleton-membrane-controlled slow-release as carriers and a preparation method thereof. Background technique [0003] Compound Danshen Tablets was developed by Shanghai No. Promote blood circulation and remove blood stasis, regulate qi and relieve pain, and are often used in the treatment of coronary heart disease and angina pectoris. It has definite curative effect and wide clinical application. At present, sustained-release preparations are all made of artificial...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/38A61K36/537A61K31/045A61K9/00A61K9/16A61P9/10A61K9/52A61K9/22A61K9/10
Inventor 朱盛山李苑新袁旭江
Owner GUANGDONG PHARMA UNIV
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